Whole-genome sequencing of Escherichia coli from retail meat in China reveals the dissemination of clinically important antimicrobial resistance genes,International Journal of Food Microbiology

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Whole-genome sequencing of Escherichia coli from retail meat in China reveals the dissemination of clinically important antimicrobial resistance genes
International Journal of Food Microbiology ( IF 5.4 ) Pub Date : 2024-02-22 , DOI: 10.1016/j.ijfoodmicro.2024.110634
Qin Wang , Ying-Yue Han , Tie-Jun Zhang , Xuan Chen , Heng Lin , Hong-Ning Wang , Chang-Wei Lei

is one of the important reservoirs of antimicrobial resistance genes (ARG), which often causes food-borne diseases and clinical infections. Contamination with carrying clinically important antimicrobial resistance genes in retail meat products can be transmitted to humans through the food chain, posing a serious threat to public health. In this study, a total of 330 strains were isolated from 464 fresh meat samples from 17 food markets in China, two of which were identified as enterotoxigenic and enteropathogenic . Whole genome sequencing revealed the presence of 146 different sequence types (STs) including 20 new STs, and 315 different clones based on the phylogenetic analysis, indicating the high genetic diversity of from retail meat products. Antimicrobial resistance profiles showed that 82.42 % were multidrug-resistant strains. A total of 89 antimicrobial resistance genes were detected and 12 strains carried clinically important antimicrobial resistance genes , , , and (X4), respectively. Nanopore sequencing revealed that these resistance genes are located on different plasmids with the ability of horizontal transfer, and their genetic structure and environment are closely related to plasmids isolated from humans. Importantly, we reported for the first time the presence of plasmid-mediated in from retail meat. This study revealed the high genetic diversity of food-borne in retail meat and emphasized their risk of spreading clinically important antimicrobial resistance genes.

更新日期：2024-02-22

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