A set of thiochromano[2,3-c]pyrrolidine-1,3-diones, incorporating α-hydroxy esters and their acids at the C-9 position, was prepared via direct interaction involving benzo[b]thiofuran-2,3-diones, maleimides, and alkyl alcohols in water at 90 °C. Structures of the new products were deduced from HRMS and NMR spectral data and confirmed by single-crystal X-ray crystallography. An insight into a proposed pathway involving a sequential Michael conjugate addition (initiated by the sulfur atom) and an aldol-type reaction is presented.

中文翻译：

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利用苯并[b]噻喃-2,3-二酮、马来酰亚胺和烷基醇/水混合物合成烷基硫代苯并[2,3-c]吡咯-9-羧酸酯衍生物

一组硫代苯并[2,3- c ]吡咯烷-1,3-二酮，在C-9位置掺入α-羟基酯及其酸，通过涉及苯并[ b ]硫代呋喃-2,3-的直接相互作用制备二酮、马来酰亚胺和烷基醇在 90 °C 的水中。新产品的结构由 HRMS 和 NMR 光谱数据推导出来，并通过单晶 X 射线晶体学证实。深入探讨了涉及连续迈克尔共轭加成（由硫原子引发）和羟醛型反应的拟议途径。