Purpose

Sleep apnea-specific hypoxic burden (SASHB) is a polysomnographic metric that comprehensively measures the degree of nocturnal desaturation caused by obstructive sleep apnea. This research was conducted to elucidate the relationship between SASHB and coronary artery disease (CAD) severity.

Methods

We carried out a prospective study of hospitalized patients with CAD of unstable angina who were expected to undergo invasive coronary angiography at Beijing Anzhen Hospital from February to September 2023. SASHB values were calculated using a self-programmed C + + program. Multivariable logistic regression analysis was applied to identify the association between SASHB and the prevalence of severe CAD, documented by the Gensini Score, and the SYNTAX (Synergy between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) Score.

Results

This study enrolled 137 patients with a median age of 59 years, 96 (70.1%) of whom were male. A total of 125 (91.2%) patients had coronary stenosis of ≥ 50% in at least one location. Patients with a high SASHB of ≥ 18% min/h had a significantly higher Gensini Score (32.0 vs. 18.5, P = 0.002) and SYNTAX Score (14.0 vs. 7.0, P = 0.002) than those with a low SASHB. After adjusting for multiple covariates, a high SASHB was significantly associated with the prevalence of severe CAD, determined by a Gensini Score ≥ 21 (OR 2.67, P = 0.008) or a SYNTAX Score > 22 (OR 4.03, P = 0.016).

Conclusion

Our findings revealed a robust and independent association between SASHB and CAD severity in patients with unstable angina, highlighting the potential value of SASHB as a predictor of risk and a target for interventions aimed at preventing cardiovascular diseases.

Trial registration

Chinese Clinical Trial Registry No. ChiCTR2300067991 on February 2, 2023.

中文翻译：

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睡眠呼吸暂停特异性低氧负荷与冠状动脉疾病严重程度之间的关联

目的

睡眠呼吸暂停特异性低氧负担（SASHB）是一种多导睡眠图指标，可综合测量阻塞性睡眠呼吸暂停引起的夜间低饱和程度。本研究旨在阐明 SASHB 与冠状动脉疾病 (CAD) 严重程度之间的关系。

方法

我们对2023年2月至2023年9月在北京安贞医院住院的不稳定型心绞痛CAD患者进行了侵入性冠状动脉造影的前瞻性研究。使用自编C++程序计算SASHB值。应用多变量逻辑回归分析来确定 SASHB 与严重 CAD 患病率之间的关联，由 Gensini 评分和 SYNTAX（经皮冠状动脉介入治疗与红豆杉和心脏手术之间的协同）评分记录。

结果

该研究纳入了 137 名患者，中位年龄为 59 岁，其中 96 名（70.1%）为男性。共有 125 名 (91.2%) 患者至少在一个部位出现冠状动脉狭窄 ≥ 50%。SASHB ≥ 18% min/h 高的患者比 SASHB 低的患者具有显着更高的 Gensini 评分（32.0 vs. 18.5，P  = 0.002）和 SYNTAX 评分（14.0 vs. 7.0，P  = 0.002）。调整多个协变量后，高 SASHB 与严重 CAD 的患病率显着相关，具体取决于 Gensini 评分 ≥ 21（OR 2.67，P  = 0.008）或 SYNTAX 评分 > 22（OR 4.03，P  = 0.016）。

结论

我们的研究结果揭示了不稳定心绞痛患者 SASHB 与 CAD 严重程度之间存在强有力且独立的关联，强调了 SASHB 作为风险预测因子和旨在预防心血管疾病的干预措施目标的潜在价值。

试用注册

2023年2月2日中国临床试验注册号ChiCTR2300067991。