Contractile activity of both the epithelium and underlying mesenchyme are required for epithelial deformation and cell fate acquisition during early mouse hair follicle development. Subsequently, localized basement membrane remodelling facilitates the release of tension-generated pressure to promote cell divisions, tissue fluidification and downgrowth of the developing hair follicle.

中文翻译：

---

收缩性驱动毛囊形态发生和细胞命运的时空协调

在早期小鼠毛囊发育过程中，上皮和下面的间质的收缩活性是上皮变形和细胞命运获得所必需的。随后，局部基底膜重塑有助于释放张力产生的压力，从而促进细胞分裂、组织流化和发育中毛囊的向下生长。