Leishmaniasis is a zoonotic disease caused by Leishmania ., impacts multiple systems and organs. While hematological and biochemical profiles aren’t definitive for diagnosis, recent studies have identified the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) as predictors of morbidity and mortality in critically ill human and dog patients. This study examined 100 dogs diagnosed with leishmaniasis, categorized by the International Renal Interest Society (IRIS) stages 1–4. Additionally, the dogs were divided based on whether they survived less or more than one year (L1Y and G1Y). Control group consisted of 43 dogs. The NLR increased as the disease progressed (IRIS 1–4), presenting statistically significant differences (P<0.05) when compared to the control group (2,37±2,08) IRIS 3 and 4 (4,59±13,39 and 6,99±12,86, respectively), and G1Y and L1Y (3,60±4,02 and 4,87±5,82, respectively). Significant changes in SII were only evident in short-term survivors (L1Y 951,93±1402) and advanced renal disease cases (IRIS 4 stage 1073,68±1901,09). Conversely, PLR remained largely unchanged. In conclusion, these results suggest that the neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) may serve as potential markers for assessing disease progression and prognosis in dogs diagnosed with leishmaniasis.

中文翻译：

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利什曼病犬中性粒细胞与淋巴细胞比率、血小板与淋巴细胞比率和全身免疫炎症指数的临床重要性

利什曼病是一种由利什曼原虫引起的人畜共患疾病，影响多个系统和器官。虽然血液学和生化特征对于诊断并不确定，但最近的研究已确定中性粒细胞与淋巴细胞比率（NLR）、血小板与淋巴细胞比率（PLR）和全身免疫炎症指数（SII）作为发病率和死亡率的预测因子。危重人类和狗患者的死亡率。这项研究检查了 100 只被诊断患有利什曼病的狗，按照国际肾脏兴趣协会 (IRIS) 的 1-4 阶段进行分类。此外，根据狗的存活时间少于或超过一年（L1Y 和 G1Y）进行分类。对照组由 43 只狗组成。 NLR 随着疾病进展而增加 (IRIS 1–4)，与对照组 (2,37±2,08) 相比，呈现统计学显着差异 (P<0.05) IRIS 3 和 4 (4,59±13,39)和 6,99±12,86），以及 G1Y 和 L1Y（分别为 3,60±4,02 和 4,87±5,82）。 SII 的显着变化仅在短期幸存者 (L1Y 951,93±1402) 和晚期肾病病例 (IRIS 4 阶段 1073,68±1901,09) 中出现。相反，PLR 基本保持不变。总之，这些结果表明，中性粒细胞与淋巴细胞比率（NLR）和全身免疫炎症指数（SII）可以作为评估诊断患有利什曼病的狗的疾病进展和预后的潜在标志物。