Aging is a multifactorial process characterized by an age-related decline in organismal fitness. This deterioration is the major risk factor for chronic diseases such as cardiovascular pathologies, neurodegeneration or cancer, and it represents one of the main challenges of modern society. Therefore, understanding why and how we age would be a fundamental pillar to design strategies to promote a healthy aging. In the last decades, the study of the molecular bases of disease has been revolutionized by the discovery of different types of non-coding RNAs (ncRNAs) with regulatory potential. In this work, we will review the implication of ncRNAs in aging, with the aim to provide a first approach to the different aging-associated ncRNAs, their mechanism of action and their potential relevance as therapeutic targets and disease biomarkers.

中文翻译：

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非编码 RNA 对衰老和寿命的贡献

衰老是一个多因素的过程，其特征是与年龄相关的机体健康水平下降。这种恶化是心血管疾病、神经退行性疾病或癌症等慢性疾病的主要危险因素，也是现代社会的主要挑战之一。因此，了解我们衰老的原因和方式将是设计促进健康老龄化策略的基本支柱。在过去的几十年里，由于不同类型的具有调控潜力的非编码 RNA (ncRNA) 的发现，疾病分子基础的研究发生了革命性的变化。在这项工作中，我们将回顾 ncRNA 在衰老中的影响，旨在为研究不同的衰老相关 ncRNA、它们的作用机制以及它们作为治疗靶点和疾病生物标志物的潜在相关性提供第一种方法。