To evaluate associations between ocular manifestations of Marfan syndrome and cardiovascular complications. Retrospective cohort study. The TriNetX Analytics platform, a federated health research network of aggregated deidentified electronic health record data of more than 119 million patients, was used to identify patients diagnosed with Marfan syndrome. Univariate logistic regression models were used to evaluate the association of ocular manifestations of Marfan syndrome (such as retinal tears/detachment, lens dislocation, and myopia), with cardiovascular comorbidities. Additional sensitivity analyses were performed using propensity matching. Odds ratios and 95% CIs were calculated for incidence of cardiovascular comorbidities (including aortic dissection, valvular disease, and arrhythmias) following diagnosis of Marfan syndrome. A total of 19,105 patients were identified who were diagnosed with Marfan disease without ocular manifestations, and an additional 3887 Marfan patients with ocular comorbidities. Patients who were diagnosed with ocular disease included 883 with ectopic lens, 417 with retinal tear or detachment, 683 with aphakia, 534 with pseudophakia, and 2465 with myopia. Patients with any ocular manifestations of Marfan were significantly more likely to be diagnosed with all cardiovascular comorbidities modeled including aortic aneurysm and dissection (OR 2.035; < .0001), mitral valve prolapse (OR 2.725; < .0001), tricuspid valve disorders (OR 2.142; < .0001), cardiac arrhythmias (OR 1.836; < .0001), and all cardiovascular outcomes combined (OR 2.194; < .0001). In a large and diverse cohort of patients with Marfan syndrome, ocular manifestations of the disorder appear strongly associated with cardiovascular comorbidities.

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马凡氏综合征的眼部表现与心血管并发症的关联

评估马凡综合征的眼部表现与心血管并发症之间的关联。回顾性队列研究。 TriNetX Analytics 平台是一个联合健康研究网络，汇集了超过 1.19 亿患者的去识别化电子健康记录数据，用于识别诊断为马凡氏综合症的患者。使用单变量逻辑回归模型来评估马凡综合征的眼部表现（例如视网膜撕裂/脱离、晶状体脱位和近视）与心血管合并症的关联。使用倾向匹配进行了额外的敏感性分析。计算马凡综合征诊断后心血管合并症（包括主动脉夹层、瓣膜病和心律失常）发生率的比值比和 95% CI。共有 19,105 名被诊断为无眼部表现的马凡氏病患者，以及另外 3887 名患有眼部合并症的马凡氏病患者。诊断为眼部疾病的患者包括异位晶状体883例、视网膜撕裂或脱离417例、无晶状体眼683例、假晶状体534例、近视2465例。具有任何马凡眼部表现的患者明显更有可能被诊断为所有心血管合并症模型，包括主动脉瘤和夹层（OR 2.035；< .0001）、二尖瓣脱垂（OR 2.725；< .0001）、三尖瓣疾病（OR 2.142；< .0001）、心律失常（OR 1.836；< .0001）以及所有心血管结局的综合（OR 2.194；< .0001）。在大量不同的马凡综合征患者队列中，该疾病的眼部表现似乎与心血管合并症密切相关。