The study presents a significant advancement in drug delivery and therapeutic efficacy through the successful synthesis of (Jacq.) Kunth. ex. Walp., stem zinc oxide nanoparticles(GSS ZnONPs). The phenolic compounds present in stem (GSS) particularly vanillic acid, apegnin-7--glucoside, syringic acid, and -coumaric acid which were identified by HPLC. These compounds shown antioxidant and anti-inflammatory properties. GSS ZnONPs demonstrate pronounced gastroprotective effects against ethanol-induced gastritis, evidenced by the reduction in gastric lesions and mucosal injury upon its treatment. Histopathological evaluation and immunohistochemical analysis of nuclear factor erythroid 2-related factor 2 (Nrf2) expression further validate these results, revealing the amelioration of ethanol-induced gastritis and improved gastric tissue condition due to their treatment. Noteworthy is the dose-dependent response of GSS ZnONPs, showcasing their efficacy even at lower doses against ethanol-induced gastritis which is confirmed by different biomarkers. These findings have substantial implications for mitigating dosage-related adverse effects while preserving therapeutic benefits, offering a more favorable treatment approach. This study aims to investigate the potential gastroprotective activity of GSS ZnONPs against gastritis.

中文翻译：

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使用 Gliricidia sepium (Jacq.) Kunth 的乙醇提取物绿色合成氧化锌纳米颗粒。前任。 Walp.，茎：大鼠乙醇性胃炎的特征及其胃保护作用

该研究通过成功合成 (Jacq.) Kunth，在药物输送和治疗功效方面取得了重大进展。前任。 Walp.，干氧化锌纳米颗粒（GSS ZnONPs）。通过 HPLC 鉴定了茎 (GSS) 中存在的酚类化合物，特别是香草酸、apegnin-7-葡萄糖苷、丁香酸和香豆酸。这些化合物显示出抗氧化和抗炎特性。 GSS ZnONPs 对乙醇诱发的胃炎具有显着的胃保护作用，其治疗后胃损伤和粘膜损伤的减少就证明了这一点。核因子红细胞 2 相关因子 2 (Nrf2) 表达的组织病理学评估和免疫组织化学分析进一步验证了这些结果，揭示了乙醇诱导的胃炎的改善和胃组织状况的改善。值得注意的是 GSS ZnONP 的剂量依赖性反应，即使在较低剂量下也显示出其对乙醇引起的胃炎的功效，这已被不同的生物标志物证实。这些发现对于减轻与剂量相关的不良反应，同时保留治疗效果，提供更有利的治疗方法具有重大意义。本研究旨在探讨 GSS ZnONPs 对胃炎的潜在胃保护活性。