This study was aimed to review and analyze the evidence of the psychosocial interventions for survivors of childhood cancer. Electronic databases (PubMed, Embase, Medline, Web of Science, Science Direct, and Scopus) and manuel search were performed for psychosocial randomised controlled trials (RCTs) conducted with survivors who were diagnosed under the age of 18 and have completed treatment. Meta-analyses were performed to evaluate the effects of interventions on psychosocial health outcomes. The trials were published in English between 1 January 2000 to 30 June 2022 were included. Extracted data were analyzed using Review Manager 5.4. Ten trials conducted with 955 childhood cancer survivors were included in the systematic review. Meta-analysis of six RCTs showed no difference in the general quality of life (SMD, 0.07; 95% CI: [-0.09 to 0.23], 0%, (p > 0.05)) and three RCTs showed no difference in the physical activity self-efficacy (SMD, 0.12; 95% CI: [-0.35 to 0.58], 75%, (p > 0.05)) between intervention and control group. Interventions longer than 24 weeks (including follow-up) were effective in the quality of life and physical activity self-efficacy of the survivors. The overall quality of the evidence was low due to overall low risk of bias for only half of the studies (50%). Psychosocial interventions were not effective on quality of life and physical activity self-efficacy of childhood cancer survivors, however, long-term interventions provided improvement in these outcomes. The protocol for the meta-analysis was registered at PROSPERO (CRD42022375053/22 Nov 2022).

中文翻译：

---

儿童癌症幸存者的心理社会干预：随机对照试验的系统回顾和荟萃分析

本研究旨在回顾和分析儿童癌症幸存者心理社会干预的证据。我们对电子数据库（PubMed、Embase、Medline、Web of Science、Science Direct 和 Scopus）和手册搜索进行了心理社会随机对照试验 (RCT)，这些试验的对象是 18 岁以下被诊断出并已完成治疗的幸存者。进行荟萃分析以评估干预措施对心理社会健康结果的影响。这些试验以英文发表，时间为2000年1月1日至2022年6月30日。使用 Review Manager 5.4 分析提取的数据。系统评价纳入了对 955 名儿童癌症幸存者进行的 10 项试验。六项随机对照试验的荟萃分析显示总体生活质量没有差异（SMD，0.07；95% CI：[-0.09 至 0.23]，0%，（p > 0.05）），三项随机对照试验显示体力活动没有差异干预组和对照组之间的自我效能（SMD，0.12；95% CI：[-0.35 至 0.58]，75%，(p > 0.05)）。超过 24 周的干预措施（包括随访）对幸存者的生活质量和身体活动自我效能有效。由于只有一半研究 (50%) 的总体偏倚风险较低，因此证据的整体质量较低。心理社会干预对儿童癌症幸存者的生活质量和身体活动自我效能无效，但长期干预可以改善这些结果。荟萃分析方案已在 PROSPERO 注册（CRD42022375053/2022 年 11 月 22 日）。