The heterogeneity and plasticity of neutrophils in tumor–host interactions and how tumor signals induce reprogramming of neutrophil subpopulations need further investigation. recently reported that a hypoxic-glycolytic niche in mouse tumors could reprogram mature and immature neutrophils into a long-lived and terminally-differentiated subset, which promoted angiogenesis and tumor growth.

中文翻译：

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肿瘤生态位可以重新编程长寿命的促肿瘤中性粒细胞

中性粒细胞在肿瘤-宿主相互作用中的异质性和可塑性以及肿瘤信号如何诱导中性粒细胞亚群的重编程需要进一步研究。最近报道，小鼠肿瘤中的缺氧糖酵解生态位可以将成熟和未成熟的中性粒细胞重新编程为长寿和终末分化的子集，从而促进血管生成和肿瘤生长。