The use of combination of readily available ligands in palladium catalyzed C–H arylation of 1,3,4-oxadiazole with iodoarenes as well as bromoarenes is reported. The combination of phenanthroline monohydrate (Phen.HO) and triphenyl phosphine (PPh) with Pd catalyst exhibited improved catalytical activity compared to a single ligand used separately in the reaction. A wide range of 2,5-diarylated-1,3,4-oxadiazoles with a variation of aryl component at C-5 position is synthesized using this method. Overall, this method exhibits a broad substrate scope and high functional group tolerance. In addition, this method is used for the synthesis of carbazole/oxadiazole and biphenyl/oxadiazole based hybrid compounds which are known for their interesting photophysical properties.

中文翻译：

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使用配体组合方法钯催化 1,3,4-恶二唑的直接 C-H 芳基化

据报道，在钯催化的 1,3,4-恶二唑与碘芳烃以及溴芳烃的 C-H 芳基化反应中使用易于获得的配体组合。与反应中单独使用的单一配体相比，菲咯啉一水合物 (Phen.HO) 和三苯基膦 (PPh) 与 Pd 催化剂的组合表现出更高的催化活性。使用该方法合成了多种 2,5-二芳基化-1,3,4-恶二唑，其 C-5 位芳基成分有所不同。总体而言，该方法表现出广泛的底物范围和高官能团耐受性。此外，该方法还用于合成咔唑/恶二唑和联苯/恶二唑基杂化化合物，这些化合物以其有趣的光物理性质而闻名。