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Association Between Serum Klotho and Chronic Obstructive Pulmonary Disease in US Middle-Aged and Older Individuals: A Cross-Sectional Study from NHANES 2013–2016
International Journal of Chronic Obstructive Pulmonary Disease ( IF 2.8 ) Pub Date : 2024-02-26 , DOI: 10.2147/copd.s451859 Yushan Shi , Zhangmeng Xu , Shuangshuang Pu , Kanghong Xu , Yanan Wang , Chunlai Zhang
International Journal of Chronic Obstructive Pulmonary Disease ( IF 2.8 ) Pub Date : 2024-02-26 , DOI: 10.2147/copd.s451859 Yushan Shi , Zhangmeng Xu , Shuangshuang Pu , Kanghong Xu , Yanan Wang , Chunlai Zhang
Purpose: This study sought to examine the potential association between serum Klotho levels and the prevalence of COPD in the United States.
Patients and Methods: This study was a cross-sectional analysis involving 4361 adults aged 40– 79 years participating in the US National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2016. Our investigation utilized multivariate logistic regression and restricted cubic spline (RCS) regression to explore the potential correlation between serum Klotho concentrations and the prevalence of COPD. Additionally, we conducted stratified and interaction analyses to evaluate the consistency and potential modifiers of this relationship.
Results: In this study encompassing 4631 patients (with an average age of 57.6 years, 47.5% of whom were male), 445 individuals (10.2%) were identified as having COPD. In the fully adjusted model, ln-transformed serum Klotho was negatively associated with COPD (OR = 0.71; 95% CI: 0.51– 0.99; p = 0.043). Meanwhile, compared with quartile 1, serum Klotho levels in quartiles 2– 4 yielded odds ratios (ORs) (95% CI) for COPD were 0.84 (0.63~1.11), 0.76 (0.56~1.02), 0.84 (0.62~1.13), respectively. A negative relationship was observed between the ln-transformed serum Klotho and occurrence of COPD (nonlinear: p = 0.140). the association between ln-transformed serum Klotho and COPD were stable in stratified analyses.
Conclusion: Serum Klotho was negatively associated with the incidence of COPD, when ln-transformed Klotho concentration increased by 1 unit, the risk of COPD was 29% lower.
Keywords: α-Klotho (Klotho), chronic obstructive pulmonary disease, cross-sectional study, National Health and Nutrition Survey, NHANES
中文翻译：
美国中老年人血清 Klotho 与慢性阻塞性肺疾病的关联：NHANES 2013-2016 的横断面研究
目的：本研究旨在探讨血清 Klotho 水平与美国 COPD 患病率之间的潜在关联。
患者和方法：本研究是一项横断面分析，涉及 4361 名 40-79 岁的成年人，参加了 2013 年至 2016 年间进行的美国国家健康和营养检查调查 (NHANES)。我们的调查利用了多元逻辑回归和限制三次样条（ RCS）回归探讨血清 Klotho 浓度与 COPD 患病率之间的潜在相关性。此外，我们进行了分层和交互分析，以评估这种关系的一致性和潜在的修正因素。
结果：在这项涵盖 4631 名患者（平均年龄 57.6 岁，其中 47.5% 为男性）的研究中，445 名患者（10.2%）被确定患有 COPD。在完全调整的模型中，ln 转化的血清 Klotho 与 COPD 呈负相关（OR = 0.71；95% CI：0.51–0.99；p = 0.043）。同时，与第1四分位数相比，第2-4四分位数的血清Klotho水平对COPD的比值比（ORs）（95% CI）分别为0.84（0.63~1.11）、0.76（0.56~1.02）、0.84（0.62~1.13）、分别。ln 转化的血清 Klotho 与 COPD 的发生之间观察到负相关（非线性：p = 0.140）。在分层分析中，ln 转化的血清 Klotho 与 COPD 之间的关联是稳定的。
结论：血清Klotho与COPD发病呈负相关，ln转化Klotho浓度每增加1个单位，COPD风险降低29%。
关键词： α-Klotho（Klotho），慢性阻塞性肺疾病，横断面研究，国家健康和营养调查，NHANES
更新日期：2024-02-26
Patients and Methods: This study was a cross-sectional analysis involving 4361 adults aged 40– 79 years participating in the US National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2016. Our investigation utilized multivariate logistic regression and restricted cubic spline (RCS) regression to explore the potential correlation between serum Klotho concentrations and the prevalence of COPD. Additionally, we conducted stratified and interaction analyses to evaluate the consistency and potential modifiers of this relationship.
Results: In this study encompassing 4631 patients (with an average age of 57.6 years, 47.5% of whom were male), 445 individuals (10.2%) were identified as having COPD. In the fully adjusted model, ln-transformed serum Klotho was negatively associated with COPD (OR = 0.71; 95% CI: 0.51– 0.99; p = 0.043). Meanwhile, compared with quartile 1, serum Klotho levels in quartiles 2– 4 yielded odds ratios (ORs) (95% CI) for COPD were 0.84 (0.63~1.11), 0.76 (0.56~1.02), 0.84 (0.62~1.13), respectively. A negative relationship was observed between the ln-transformed serum Klotho and occurrence of COPD (nonlinear: p = 0.140). the association between ln-transformed serum Klotho and COPD were stable in stratified analyses.
Conclusion: Serum Klotho was negatively associated with the incidence of COPD, when ln-transformed Klotho concentration increased by 1 unit, the risk of COPD was 29% lower.
Keywords: α-Klotho (Klotho), chronic obstructive pulmonary disease, cross-sectional study, National Health and Nutrition Survey, NHANES
中文翻译：
美国中老年人血清 Klotho 与慢性阻塞性肺疾病的关联：NHANES 2013-2016 的横断面研究
目的：本研究旨在探讨血清 Klotho 水平与美国 COPD 患病率之间的潜在关联。
患者和方法：本研究是一项横断面分析，涉及 4361 名 40-79 岁的成年人，参加了 2013 年至 2016 年间进行的美国国家健康和营养检查调查 (NHANES)。我们的调查利用了多元逻辑回归和限制三次样条（ RCS）回归探讨血清 Klotho 浓度与 COPD 患病率之间的潜在相关性。此外，我们进行了分层和交互分析，以评估这种关系的一致性和潜在的修正因素。
结果：在这项涵盖 4631 名患者（平均年龄 57.6 岁，其中 47.5% 为男性）的研究中，445 名患者（10.2%）被确定患有 COPD。在完全调整的模型中，ln 转化的血清 Klotho 与 COPD 呈负相关（OR = 0.71；95% CI：0.51–0.99；p = 0.043）。同时，与第1四分位数相比，第2-4四分位数的血清Klotho水平对COPD的比值比（ORs）（95% CI）分别为0.84（0.63~1.11）、0.76（0.56~1.02）、0.84（0.62~1.13）、分别。ln 转化的血清 Klotho 与 COPD 的发生之间观察到负相关（非线性：p = 0.140）。在分层分析中，ln 转化的血清 Klotho 与 COPD 之间的关联是稳定的。
结论：血清Klotho与COPD发病呈负相关，ln转化Klotho浓度每增加1个单位，COPD风险降低29%。
关键词： α-Klotho（Klotho），慢性阻塞性肺疾病，横断面研究，国家健康和营养调查，NHANES
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