Plastics, while providing modern conveniences, have become an inescapable source of global concern due to their role in environmental pollution. Particularly, the focus on bisphenol A (BPA) reveals its biohazardous nature and association with liver issues, specifically steatosis. However, research indicates that BPA is just one facet of the problem, as other bisphenol analogues, microplastics, nanoplastics and additional plastic derivatives also pose potential risks. Notably, BPA is implicated in every stage of non‐alcoholic fatty liver disease (NAFLD) onset and progression, surpassing hepatitis B virus as a primary cause of chronic liver disease worldwide. As plastic contamination tops the environmental contaminants list, urgent action is needed to assess causative factors and mitigate their impact. This review delves into the molecular disruptions linking plastic pollutant exposure to liver diseases, emphasizing the broader connection between plastics and the rising prevalence of NAFLD.

中文翻译：

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塑料化合物与肝脏疾病：双酚 A 是否是唯一的罪魁祸首

塑料在提供现代便利的同时，由于其在环境污染中的作用而不可避免地成为全球关注的焦点。特别是，对双酚 A (BPA) 的关注揭示了其生物危害性以及与肝脏问题（特别是脂肪变性）的关联。然而，研究表明，BPA 只是问题的一个方面，其他双酚类似物、微塑料、纳米塑料和其他塑料衍生物也构成潜在风险。值得注意的是，BPA 与非酒精性脂肪性肝病 (NAFLD) 发病和进展的各个阶段有关，超过乙型肝炎病毒，成为全球慢性肝病的主要原因。由于塑料污染位居环境污染物之首，因此需要采取紧急行动来评估致病因素并减轻其影响。这篇综述深入研究了塑料污染物暴露与肝脏疾病之间的分子破坏，强调塑料与 NAFLD 患病率上升之间更广泛的联系。