The synthesis of novel, high-yield derivatives of chromenoazepine was investigated in this work. CuO/TiO₂@MWCNTs was used as a nanocatalyst in a multicomponent reaction involving 4-aminocumarine, activated acetylenic chemicals, and alkyl bromide in room temperature water to create these novel compounds. Using MCRs of 4-aminocumarine, isothiocyanate, and alkyl bromide in the presence of CuO/TiO₂@MWCNTs as nanocatalysts in room-temperature water, chromenothiazepines were synthesized under comparable conditions. The freshly synthesized azepine exhibits antioxidant activity since its NH group has undergone two evaluation processes. Additionally, using two types of Gram-negative bacteria in a disk distribution procedure, the antibacterial activity of recently developed azepines was evaluated, and these compounds also inhibited the growth of Gram-positive bacteria. This method’s benefits include quick reaction times, large product yields, and straightforward catalyst and product separation through easy steps.

这项工作研究了新型、高产率的铬氮杂卓衍生物的合成。CuO/TiO ₂ @MWCNTs 被用作多组分反应中的纳米催化剂，该反应涉及室温水中的 4-氨基香豆素、活化的炔类化学品和烷基溴，以产生这些新型化合物。_{在 CuO/TiO 2} @MWCNTs 作为纳米催化剂的情况下，在室温水中使用 4-氨基香豆素、异硫氰酸酯和烷基溴的 MCR ，在类似的条件下合成了铬并噻嗪类药物。新合成的氮杂卓具有抗氧化活性，因为其NH基团经过了两次评估过程。此外，在盘分配过程中使用两种革兰氏阴性菌，评估了最近开发的氮卓类化合物的抗菌活性，这些化合物也抑制了革兰氏阳性菌的生长。该方法的优点包括反应时间短、产品收率高以及通过简单的步骤即可实现催化剂和产品的直接分离。