Despite substantial advancements in gastric cancer treatment in recent years, our understanding of the disease’s pathophysiology and progression processes remains limited, and the prognosis for gastric cancer patients remains poor. This study investigated potential prognostic indicators based on m7G-associated long non-coding RNA (lncRNA) and its relationship with gastric cancer (STAD). The researchers used RNA-seq and prognostic data from TCGA, employing Cox regression, co-expression network analysis, and multivariate Cox regression to identify relevant lncRNAs. We compiled four m7G-related lncRNAs into a single signature. We found it may be used as a prognostic indicator for gastric cancer. The m7G-related lncRNA profile had an area under the curve of 0.710, significantly more diagnostic than clinicopathological markers. The study also found that the TMB and tumor microenvironment were associated with gastric cancer risk, highlighting their signature’s potential utility for personalized treatment and disease monitoring. This study provides a novel signature of m7G-related lncRNAs that can be used as a prognostic indicator for gastric cancer and may help guide the development of targeted immunotherapy for the condition.

中文翻译：

---

一种新的 N7-甲基鸟苷相关特征可预测胃癌的预后

尽管近年来胃癌治疗取得了实质性进展，但我们对该疾病的病理生理学和进展过程的了解仍然有限，胃癌患者的预后仍然较差。本研究调查了基于 m7G 相关长非编码 RNA (lncRNA) 的潜在预后指标及其与胃癌 (STAD) 的关系。研究人员使用 RNA-seq 和来自 TCGA 的预后数据，采用 Cox 回归、共表达网络分析和多元 Cox 回归来识别相关的 lncRNA。我们将四个 m7G 相关 lncRNA 编译成一个签名。我们发现它可以用作胃癌的预后指标。m7G 相关 lncRNA 谱的曲线下面积为 0.710，明显比临床病理标志物更具诊断性。该研究还发现 TMB 和肿瘤微环境与胃癌风险相关，突出了它们的特征在个性化治疗和疾病监测方面的潜在用途。这项研究提供了 m7G 相关 lncRNA 的新特征，可用作胃癌的预后指标，并可能有助于指导针对该疾病的靶向免疫疗法的开发。