A biomarker of cognition in Multiple Sclerosis (MS) that is independent from the response of people with MS (PwMS) to test questions would provide a more holistic assessment of cognitive decline. One suggested method involves event-related potentials (ERPs). This systematic review tried to answer five questions about the use of ERPs in distinguishing PwMS from controls: which stimulus modality, which experimental paradigm, which electrodes, and which ERP components are most discriminatory, and whether amplitude or latency is a better measure. Our results show larger pooled effect sizes for visual stimuli than auditory stimuli, and larger pooled effect sizes for latency measurements than amplitude measurements. We observed great heterogeneity in methods and suggest that future research would benefit from more uniformity in methods and that results should be reported for the individual subtypes of PwMS. With more standardised methods, ERPs have the potential to be developed into a clinical tool in MS.

中文翻译：

---

事件相关电位在多发性硬化症患者认知表现调查中的应用：系统评价

多发性硬化症（MS）认知的生物标志物独立于多发性硬化症患者（PwMS）对测试问题的反应，将为认知衰退提供更全面的评估。一种建议的方法涉及事件相关电位（ERP）。本系统综述试图回答有关使用 ERP 区分 PwMS 和对照的五个问题：哪种刺激方式、哪种实验范式、哪种电极和哪种 ERP 组件最具歧视性，以及振幅或延迟是否是更好的衡量标准。我们的结果显示，视觉刺激的汇集效应大小比听觉刺激更大，延迟测量的汇集效应大小比幅度测量更大。我们观察到方法存在很大的异质性，并建议未来的研究将受益于方法的更加统一，并且应该针对 PwMS 的各个亚型报告结果。通过更标准化的方法，ERP 有潜力发展成为 MS 的临床工具。