Background

The proportion of young females among the patients who undergo percutaneous coronary intervention (PCI) is relatively small, and information on their clinical characteristics is limited. This study investigated the clinical characteristics and prognostic factors for future cardiac events in young females who underwent PCI.

Methods

This multicenter observational study included 187 consecutive female patients aged < 60 years who underwent PCI in seven hospitals. The primary composite endpoint was the incidence of cardiac death, nonfatal myocardial infarction, and target vessel revascularization.

Results

The mean patient age was 52.1 ± 6.1 years and 89 (47.6%) had diabetes, and renal dysfunction (an estimated glomerular filtration rate < 60 mL/min/1.73 m²) was observed in 38 (20.3%). During a median follow-up of 3.3 years, the primary endpoint occurred in 28 patients. The Cox proportional hazards models showed that renal dysfunction was an independent predictor for the primary endpoint (hazard ratio 3.04, 95% confidence interval 1.25–7.40, p = 0.01), as well as multivessel disease (hazard ratio 2.79, 95% confidence interval 1.12–6.93, p = 0.03). Patients with renal dysfunction had a significantly higher risk for the primary endpoint than those without renal dysfunction.

Conclusions

Renal dysfunction was strongly associated with future cardiac events in young females who underwent PCI.

中文翻译：

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年轻女性患者经皮冠状动脉介入治疗后的临床特征、未来心脏事件和预后因素

背景

接受经皮冠状动脉介入治疗（PCI）的患者中年轻女性的比例相对较小，并且有关其临床特征的信息有限。本研究调查了接受 PCI 的年轻女性的临床特征和未来心脏事件的预后因素。

方法

这项多中心观察性研究包括 187 名连续 7 家医院接受 PCI 的年龄 < 60 岁女性患者。主要复合终点是心源性死亡、非致命性心肌梗死和靶血管血运重建的发生率。

结果

患者平均年龄为 52.1 ± 6.1 岁，89 例 (47.6%) 患有糖尿病，38 例 (20.3%) 观察到肾功能障碍（估计肾小球滤过率 < 60 mL/min/1.73 m ^{2 ）。}在中位随访 3.3 年期间，主要终点发生在 28 名患者中。Cox 比例风险模型显示，肾功能不全是主要终点的独立预测因子（风险比 3.04，95% 置信区间 1.25–7.40，p = 0.01）以及多支血管疾病（风险比 2.79，95% 置信区间 1.12） –6.93，p = 0.03）。肾功能障碍患者的主要终点风险显着高于无肾功能障碍患者。

结论

对于接受 PCI 的年轻女性来说，肾功能障碍与未来的心脏事件密切相关。