Biomaterials possess distinctive properties, notably their ability to encapsulate active biological products while providing biocompatible support. The immune system plays a vital role in preventing cancer recurrence, and there is considerable demand for an effective strategy to prevent cancer recurrence, necessitating effective strategies to address this concern. This review elucidates crucial cellular signaling pathways in cancer recurrence. Furthermore, it underscores the potential of biomaterial-based tools in averting or inhibiting cancer recurrence by modulating the immune system. Diverse biomaterials, including hydrogels, particles, films, microneedles, etc., exhibit promising capabilities in mitigating cancer recurrence. These materials are compelling candidates for cancer immunotherapy, offering in situ immunostimulatory activity through transdermal, implantable, and injectable devices. They function by reshaping the tumor microenvironment and impeding tumor growth by reducing immunosuppression. Biomaterials facilitate alterations in biodistribution, release kinetics, and colocalization of immunostimulatory agents, enhancing the safety and efficacy of therapy. Additionally, how the method addresses the limitations of other therapeutic approaches is discussed.

中文翻译：

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最近用于抑制癌症复发的免疫治疗方法的生物材料辅助方法

生物材料具有独特的特性，特别是它们能够封装活性生物产品，同时提供生物相容性支持。免疫系统在预防癌症复发方面发挥着至关重要的作用，并且对预防癌症复发的有效策略有相当大的需求，因此需要有效的策略来解决这一问题。这篇综述阐明了癌症复发中关键的细胞信号传导途径。此外，它强调了基于生物材料的工具通过调节免疫系统来避免或抑制癌症复发的潜力。各种生物材料，包括水凝胶、颗粒、薄膜、微针等，在减轻癌症复发方面表现出有前景的能力。这些材料是癌症免疫疗法的有力候选者，通过透皮、植入和注射装置提供原位免疫刺激活性。它们通过重塑肿瘤微环境并通过减少免疫抑制来阻止肿瘤生长来发挥作用。生物材料有助于改变免疫刺激剂的生物分布、释放动力学和共定位，从而提高治疗的安全性和有效性。此外，还讨论了该方法如何解决其他治疗方法的局限性。