. The present analysis aimed to assess variations in PD prescriptions among incident automated PD (APD) patients who remain on PD for 120+ days. Methods: This retrospective analysis examined data from patients within a large dialysis organization that initiated PD with APD between 2015 and 2019. PD prescription data was described by calendar year, timing of PD, and residual renal function categories. Changes in prescriptions from PD initiation (day 1) to day 120 were assessed descriptively. Results: The cohort included 11,659 patients. The mean age at PD initiation increased from 2015 (56 (15) years) through 2019 (58 (15) years), whereas most other variables demonstrated no clear temporal change. Most patients (86%) had nighttime PD prescribed, with an average of 4.9 (1.3) cycles per day, a mean total treatment volume of 9.3 (2.5) L, and a median daily total dwell time of 7 (6,9.5) hours. Relative to day 1 nighttime prescriptions, there were 1) small increases in the proportion of patients receiving 3 or fewer cycles per day and those receiving 6+ cycles per day, 2) a 100 ml mean increase in fill volume per exchange, and 3) a mean 0.5 L increase in total nighttime treatment volume at day 120. When changes in nighttime APD prescriptions were examined at the patient level, 49% of patients had day 120 prescriptions that were unchanged from their initial prescription. Conclusions: In the largest analysis of incident APD prescriptions conducted in the United States to date, the vast majority of patients were prescribed nocturnal PD only with limited variability across the first 4 months of therapy. Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology...

中文翻译：

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美国大型透析组织自动腹膜透析处方的趋势

。本分析旨在评估持续使用 PD 120 天以上的自动 PD (APD) 患者的 PD 处方差异。方法：这项回顾性分析检查了 2015 年至 2019 年间一家大型透析组织内通过 APD 启动 PD 的患者的数据。PD 处方数据按日历年、PD 时间和残余肾功能类别进行描述。对从 PD 开始（第 1 天）到第 120 天的处方变化进行了描述性评估。结果：该队列包括 11,659 名患者。开始 PD 的平均年龄从 2015 年（56（15）岁）到 2019 年（58（15）岁）有所增加，而大多数其他变量没有表现出明显的时间变化。大多数患者 (86%) 接受夜间 PD 治疗，平均每天 4.9 (1.3) 个周期，平均总治疗量为 9.3 (2.5) L，中位每日总停留时间为 7 (6,9.5) 小时。相对于第 1 天夜间处方，1) 每天接受 3 个或更少周期的患者和每天接受 6 个以上周期的患者比例小幅增加，2) 每次更换的填充体积平均增加 100 毫升，以及 3)第 120 天夜间总治疗量平均增加 0.5 L。当在患者层面检查夜间 APD 处方的变化时，49% 的患者在第 120 天的处方与初始处方相比没有变化。结论：迄今为止，在美国对 APD 处方事件进行的最大规模分析中，绝大多数患者只开了夜间 PD 处方，在治疗的前 4 个月内变化有限。版权所有 © 2024 作者。由 Wolters Kluwer Health, Inc. 代表美国肾脏病学会出版...