The use of hemoperfusion adsorbents for the removal of bilirubin in patients with liver failure has become a critical treatment. However, the insufficient clearance of bilirubin and the possibility of bacterial infection during hemoperfusion limit the application. In this work, we designed a novel antibacterial bilirubin adsorbent (PSVT) through the suspension polymerization reaction between double-bond functionalized TiO₂ nanoparticles and styrene. PSVT showed an excellent bilirubin adsorption ability and antibacterial performance, ensuring efficient clearance of bilirubin in liver failure patients during hemoperfusion and preventing bacterial infection. The experimental results indicated that TiO₂ was uniformly dispersed in the microspheres, which improved the mesoporous structure and increased the specific surface area. Composite adsorbent PSVT showed an exceptional bilirubin adsorption capacity, with the maximum adsorption capacity reaching 24.3 mg/g. In addition, the introduction of TiO₂ endowed PSVT with excellent antibacterial ability; the ultimate antibacterial rates against Escherichia coli and Staphylococcus aureus reached 97.31 and 96.47%, respectively. In summary, PSVT served as a novel antibacterial bilirubin adsorbent with excellent bilirubin clearance capacity and antibacterial performance, providing excellent application prospects for treating liver failure patients.

中文翻译：

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TiO2/聚苯乙烯纳米复合抗菌材料作为血液灌流吸附剂有效去除胆红素并预防细菌感染

使用血液灌流吸附剂去除肝功能衰竭患者的胆红素已成为一种关键的治疗方法。但胆红素清除不足以及血液灌流过程中细菌感染的可能性限制了其应用。在这项工作中，我们通过双键功能化TiO ₂纳米颗粒与苯乙烯之间的悬浮聚合反应设计了一种新型抗菌胆红素吸附剂（PSVT）。PSVT表现出优异的胆红素吸附能力和抗菌性能，保证肝功能衰竭患者血液灌流期间胆红素的高效清除，防止细菌感染。实验结果表明，TiO ₂均匀分散在微球中，改善了微球的介孔结构，增加了比表面积。复合吸附剂PSVT表现出优异的胆红素吸附能力，最大吸附量达到24.3 mg/g。此外，TiO ₂的引入赋予PSVT优异的抗菌能力；对大肠杆菌和金黄色葡萄球菌的最终抗菌率分别达到97.31%和96.47%。综上所述，PSVT作为一种新型抗菌胆红素吸附剂，具有优异的胆红素清除能力和抗菌性能，为治疗肝衰竭患者提供了良好的应用前景。