o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2,Journal of Enzyme inhibition and Medicinal Chemistry

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o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-02-28 , DOI: 10.1080/14756366.2024.2313055
Md. Habibur Rahaman _{1,

2,

3} , Sara J. Thygesen ₁ , Michael J. Maxwell ₄ , Hyoyoung Kim ₁ , Prerna Mudai ₁ , Jeffrey D. Nanson _{1,

2,

3} , Xinying Jia ₄ , Parimala R. Vajjhala ₁ , Andrew Hedger _{1,

2,

3} , Irina Vetter _{3,

5} , Thomas Haselhorst ₆ , Avril A. B. Robertson _{1,

3} , Brian Dymock ₇ , Thomas Ve ₆ , Mehdi Mobli ₄ , Katryn J. Stacey _{1,

2} , Bostjan Kobe _{1,

2,

3}

Affiliation

Toll-like receptor (TLR) innate immunity signalling protects against pathogens, but excessive or prolonged signalling contributes to a range of inflammatory conditions. Structural information on th...

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