Spaceflight associated neuro-ocular syndrome (SANS) alters the vision of astronauts during long-duration spaceflights. Previously, the current authors have discussed the similarities and differences between SANS and idiopathic intracranial hypertension to try to elucidate a possible pathophysiology. Recently, a theory has been advanced that SANS may occur secondary to failure of the glymphatic system caused by venous dilatation within the brain and optic nerves. There is recent evidence to suggest glymphatic obstruction occurs in childhood hydrocephalus, multiple sclerosis and syringomyelia due to venous outflow dilatation similar to that proposed in SANS. The purpose of the current paper is to discuss the similarities and differences between the known CSF and venous pathophysiology in SANS with these other terrestrial diseases, to see if they can shed any further light on the underlying cause of this microgravity-induced disease.

航天相关神经眼综合症（SANS）会改变宇航员在长时间航天过程中的视力。此前，作者讨论了 SANS 和特发性颅内高压之间的异同，试图阐明可能的病理生理学。最近，提出了一种理论，认为 SANS 可能继发于大脑和视神经内静脉扩张引起的类淋巴系统衰竭。最近有证据表明，类淋巴管阻塞发生在儿童脑积水、多发性硬化症和脊髓空洞症中，原因是静脉流出道扩张，类似于 SANS 中提出的情况。本文的目的是讨论 SANS 中已知的脑脊液和静脉病理生理学与这些其他陆地疾病之间的异同，看看它们是否可以进一步阐明这种微重力诱发疾病的根本原因。