Purpose

To evaluate the correlation between median frequency (MF) as a measure of genioglossus (GG) fatigue and overnight repetitive respiratory events in male patients with severe obstructive sleep apnea (OSA).

Methods

GG electromyography (EMG) data were collected synchronously with polysomnography (PSG). Overnight respiratory events were divided based on whether they occurred during the first or second halves of the total number of overnight respiratory events, and differences in MF in the respiratory phase were compared in the same segments. Events were then sampled in pairs to compare MF. The correlation between MF and the order of respiratory events, as well as interindividual differences, were analyzed.

Results

Twenty-two male patients were enrolled in this study and 2210 respiratory events were recorded. Before and during respiratory events, MF decreased significantly in the second half, especially during the inspiratory phase (segments 1–4: P = 0.014, P < 0.001, P < 0.001, P < 0.001, respectively). This trend was observed in non-rapid eye movement sleep and lateral position, but not in rapid eye movement sleep or the supine position, and remained after pairing for duration, stage, and position. MF correlated negatively with the order of respiratory events during the inspiratory phase. The trend of decrease in MF only existed in patients with apnea–hypopnea index > 30 events/h.

Conclusion

Overnight repetitive respiratory events were associated with increased GG fatigue, influenced by sleep stage and body position in male patients with severe OSA. GG fatigue depends on the order and frequency of respiratory events.

中文翻译：

---

严重阻塞性睡眠呼吸暂停男性患者夜间重复性呼吸事件与颏舌肌疲劳累积之间的关系

目的

评估中位频率（MF）作为衡量颏舌肌（GG）疲劳的指标，与患有严重阻塞性睡眠呼吸暂停（OSA）的男性患者夜间重复性呼吸事件之间的相关性。

方法

GG 肌电图 (EMG) 数据与多导睡眠图 (PSG) 同步收集。根据夜间呼吸事件发生在夜间呼吸事件总数的前半部分还是后半部分进行划分，比较同一时段呼吸时相MF的差异。然后成对对事件进行采样以比较 MF。分析了 MF 与呼吸事件顺序之间的相关性以及个体间差异。

结果

本研究纳入了 22 名男性患者，记录了 2210 例呼吸事件。在呼吸事件之前和期间，MF 在后半段显着下降，尤其是在吸气相期间（第 1-4 段：分别为P  = 0.014、P  < 0.001、P  < 0.001、P  < 0.001）。这种趋势在非快速眼动睡眠和侧卧位中观察到，但在快速眼动睡眠或仰卧位中没有观察到，并且在持续时间、阶段和位置配对后仍然存在。MF 与吸气相期间呼吸事件的顺序呈负相关。仅呼吸暂停低通气指数 > 30 次/小时的患者存在 MF 下降的趋势。

结论

夜间重复性呼吸事件与严重 OSA 男性患者的 GG 疲劳增加相关，受睡眠阶段和身体姿势的影响。GG 疲劳取决于呼吸事件的顺序和频率。