Patent foramen ovale (PFO) is a common cardiac anomaly linked with cryptogenic strokes and migraine, particularly migraine with aura. This study aims to explore the spectrum of headache disorders in PFO patients, focusing on identifying patterns beyond the well-established migraine-PFO connection. A retrospective observational study was conducted on patients diagnosed with PFO. Headache types were classified using the International Classification of Headache Disorders, 3rd edition. The study analyzed headache prevalence and patterns in PFO patients, comparing those with and without a history of stroke. Of 177 participants, 63 (35.59%) reported headaches. Tension-type headache was the most common (15.25%), followed by migraine without aura (11.30%) and migraine with aura (8.47%). Notably, migraine without aura was more prevalent than migraine with aura, contrasting previous assumptions. No significant differences were found in headache types based on stroke history. The study reveals a diverse spectrum of headache types in PFO patients, with migraine without aura being more common than migraine with aura. These findings suggest a need for broader diagnostic perspective and individualized treatment approaches in PFO patients with headaches.

卵圆孔未闭 (PFO) 是一种常见的心脏异常，与隐源性中风和偏头痛（尤其是先兆偏头痛）有关。本研究旨在探讨 PFO 患者的头痛疾病谱，重点是确定偏头痛与 PFO 之间既定关系之外的模式。对诊断为 PFO 的患者进行了一项回顾性观察研究。头痛类型使用《国际头痛疾病分类》第三版进行分类。该研究分析了 PFO 患者的头痛患病率和模式，并对有和没有中风病史的患者进行了比较。在 177 名参与者中，63 名（35.59%）报告有头痛。紧张型头痛最常见（15.25%），其次是无先兆偏头痛（11.30%）和有先兆偏头痛（8.47%）。值得注意的是，无先兆偏头痛比有先兆偏头痛更常见，这与之前的假设形成鲜明对比。根据中风史，头痛类型没有发现显着差异。该研究揭示了 PFO 患者的头痛类型多种多样，其中无先兆偏头痛比有先兆偏头痛更常见。这些发现表明 PFO 头痛患者需要更广泛的诊断视角和个体化治疗方法。