Methicillin-resistant (MRSA) pathogens are considered a serious global health threat, leading to increased mortality and antimicrobial resistance. Rates in Saudi Arabia remain high, necessitating continuous surveillance. This study investigates MRSA prevalence and susceptibility at a Saudi maternity and children's hospital. A cross-sectional study was conducted on pediatric (<18 years) and maternal patients with infection from Jan. 2020 to March. 2022. Bacterial strains were obtained from patient’s clinical specimens and was identified by standard method. The BD Phoenix™ M50 was used for antibiotic susceptibility tests and MRSA detection. Data were analysed using descriptive and inferential statistics (Chi-square test) with SPSS software. Out of 152 cases, 114/152 (75 %) were pediatric and 38/152 (25 %) were maternal patients. The overall MRSA infection was 69/152 (45.4 %). Among pediatrics, 31/54 (57.4 %) MRSA cases were female; over 30/54 (56 %) were under 1 year old; and most MRSA infections were obtained from skin 29/54 (53.7 %) compared to other sites of infections (p = 0.024). Among maternal cases, 15/38 (39.5 %) were MRSA, primarily from wound infections 14/15 (93.3 %) compared to other sites of infections (p = 0.39). All MRSA isolates were sensitive to vancomycin and linezolid. While 51/60(85 %) were sensitive to Trimethoprim/ sulfamethoxazole. This investigation found a high prevalence of MRSA among pediatrics and maternal inpatients, indicating a significant burden. All MRSA isolates were susceptible to vancomycin but demonstrated variable sensitivity to other antibiotics. These findings highlight the need for ongoing surveillance, infection control strategies, and research into alternative treatment options to combat this major public health threat.

中文翻译：

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沙特阿拉伯一家妇幼医院耐甲氧西林金黄色葡萄球菌 (MRSA) 的患病率和抗菌药物敏感性模式：一项横断面研究

耐甲氧西林 (MRSA) 病原体被认为是严重的全球健康威胁，导致死亡率和抗菌素耐药性增加。沙特阿拉伯的感染率仍然很高，需要持续监测。本研究调查了沙特一家妇幼医院的 MRSA 患病率和易感性。对2020年1月至3月感染的儿科（<18岁）和孕产妇患者进行了一项横断面研究。 2022年，从患者的临床标本中获取菌株，并通过标准方法进行鉴定。 BD Phoenix™ M50 用于抗生素敏感性测试和 MRSA 检测。使用 SPSS 软件使用描述性和推论性统计（卡方检验）对数据进行分析。在 152 例病例中，114/152 (75%) 为儿科患者，38/152 (25%) 为孕产妇患者。 MRSA 总体感染率为 69/152 (45.4%)。在儿科中，31/54 (57.4%) MRSA 病例为女性；超过 30/54 (56%) 的儿童年龄在 1 岁以下；与其他感染部位相比，大多数 MRSA 感染来自皮肤 29/54 (53.7%) (p = 0.024)。在孕产妇病例中，15/38 (39.5 %) 是 MRSA，主要来自伤口感染，与其他部位感染相比，14/15 (93.3 %) (p = 0.39)。所有 MRSA 分离株均对万古霉素和利奈唑胺敏感。而51/60（85%）对甲氧苄啶/磺胺甲恶唑敏感。这项调查发现儿科和孕产妇住院患者中 MRSA 患病率很高，这表明负担很重。所有 MRSA 分离株均对万古霉素敏感，但对其他抗生素表现出不同的敏感性。这些发现强调需要持续监测、感染控制策略以及研究替代治疗方案，以应对这一重大公共卫生威胁。