The accurate diagnosis of diseases can be improved by detecting multiple biomarkers simultaneously. This study presents the development of a magnetic photoelectrochemical (PEC) immunosensor array for the simultaneous detection of amyloid-β 42 (Aβ) and microtubule-associated protein (Tau), which are markers for neurodegenerative disorders. A metal-organic framework (MOF) derivative, FeO@FeS magnetic composites with exceptional photoelectric and ferromagnetic properties was synthesized while preserving the original structure and advantages. Thus, the immunoassembly process of the sensor can be carried out in homogeneous solution and recovered by magnetic separation. For simultaneous detection, a chip is divided into multiple independent sensing sites, which have the same preparation and detection environment, allowing for the implementation of a self-calibration method. The sensor array demonstrates considerable detection ranges of 0.01–100 ng mL for Aβ and 0.05–100 ng mL for Tau, with low detection limits of 2.1 pg mL for Aβ and 7.9 pg mL for Tau. The PEC sensor array proposed in this study exhibits exceptional stability, selectivity, and reproducibility, providing a new method for detecting multiple markers.

中文翻译：

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磁光电化学传感器阵列利用寻址传感策略同时检测淀粉样蛋白-β 42 和微管相关蛋白 tau

通过同时检测多种生物标志物可以提高疾病的准确诊断。本研究开发了一种磁光电化学 (PEC) 免疫传感器阵列，用于同时检测淀粉样蛋白 β 42 (Aβ) 和微管相关蛋白 (Tau)，这两种蛋白是神经退行性疾病的标志物。合成了一种金属有机骨架（MOF）衍生物FeO@FeS磁性复合材料，具有优异的光电和铁磁性能，同时保留了原有的结构和优点。因此，传感器的免疫组装过程可以在均质溶液中进行，并通过磁分离回收。对于同时检测，将芯片分为多个独立的传感位点，这些位点具有相同的准备和检测环境，从而可以实现自校准方法。该传感器阵列显示出 Aβ 0.01–100 ng mL 和 Tau 0.05–100 ng mL 的相当大检测范围，Aβ 2.1 pg mL 和 Tau 7.9 pg mL 的低检测限。本研究提出的 PEC 传感器阵列表现出卓越的稳定性、选择性和重现性，为检测多个标记物提供了一种新方法。