Extracorporeal cardiopulmonary resuscitation (ECPR) for selected refractory out-of-hospital cardiac arrest (OHCA) is increasingly used. Detailed knowledge of health-related quality of life (HRQoL) and long-term cognitive function is limited. HRQoL and cognitive function were assessed in ECPR-survivors and OHCA-survivors with prehospital return of spontaneous circulation after standard advanced cardiac life support (sACLS). Fifteen ECPR-survivors and 22 age-matched sACLS-survivors agreed to participate in this follow-up study. Participants were examined with echocardiography, 6-minute walk test, and neuropsychological testing, and answered HRQoL (EQ-5D-5L and Short Form 36 (SF-36)), and mental health questionnaires. Most patients were male (73 % and 82 %) and median age at follow-up was similar between groups (55 years and 60 years). Low flow time was significantly longer for ECPR-survivors (86 min vs. 15 min) and lactate levels were significantly higher (14.1 mmol/l vs. 3.9 mmol/l). No between-group difference was found in physical function nor in cognitive function with scores corresponding to the 23rd worst percentile of the general population. SACLS-survivors had HRQoL on level with the Danish general population while ECPR-survivors scored lower in both EQ-5D-5L (index score 0.73 vs. 0.86, p = 0.03, visual analog scale: 70 vs. 84, p = 0.04) and in multiple SF-36 health domains (role physical, bodily pain, general health, and mental health). Despite substantially longer low flow times with thrice as high lactate levels, ECPR-survivors were similar in cognitive and physical function compared to sACLS-survivors. Nonetheless, ECPR-survivors reported lower HRQoL overall and related to mental health, pain management, and the perception of limitations in physical role.

中文翻译：

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院外心脏骤停后与健康相关的生活质量和认知功能；院前自主循环恢复与体外心肺复苏难治性逮捕的比较

体外心肺复苏（ECPR）越来越多地用于治疗特定的难治性院外心脏骤停（OHCA）。关于健康相关生活质量 (HRQoL) 和长期认知功能的详细知识是有限的。在标准高级心脏生命支持 (sACLS) 后院前恢复自主循环的 ECPR 幸存者和 OHCA 幸存者中评估了 HRQoL 和认知功能。 15 名 ECPR 幸存者和 22 名年龄匹配的 sACLS 幸存者同意参加这项后续研究。参与者接受了超声心动图、6 分钟步行测试和神经心理学测试，并回答了 HRQoL（EQ-5D-5L 和简表 36 (SF-36)）和心理健康问卷。大多数患者为男性（73% 和 82%），两组间随访时的中位年龄相似（55 岁和 60 岁）。 ECPR 幸存者的低流量时间明显更长（86 分钟 vs. 15 分钟），乳酸水平显着更高（14.1 mmol/l vs. 3.9 mmol/l）。身体功能和认知功能均未发现组间差异，其得分相当于总人口中倒数第 23 个百分位数。 SACLS 幸存者的 HRQoL 与丹麦一般人群持平，而 ECPR 幸存者在 EQ-5D-5L 中得分较低（指数得分 0.73 与 0.86，p = 0.03，视觉模拟量表：70 与 84，p = 0.04）以及多个 SF-36 健康领域（身体角色、身体疼痛、一般健康和心理健康）。尽管低流量时间明显更长，乳酸水平高出三倍，但 ECPR 幸存者的认知和身体功能与 sACLS 幸存者相似。尽管如此，ECPR 幸存者报告总体 HRQoL 较低，且与心理健康、疼痛管理和对身体角色限制的感知有关。