Arthritis, a prevalent inflammatory condition, is often linked to obesity as a contributing factor. This study aimed to assess the potential protective effects of purslane extract in male albino rats with induced arthritis and obesity. Fifty rats were randomly assigned to five groups: a control group, an induced arthritis-high-fat diet group, a high-dose purslane extract-supplemented group (300 mg/kg body weight) for 8 weeks, a low-dose purslane extract-supplemented group (150 mg/kg body weight) for 8 weeks, and a metformin-supplemented group. Arthritis was induced in the rats using Complete Freund’s Adjuvant. Plasma biomarkers, including Total Cholesterol, Triglycerides, HDL-cholesterol, LDL-cholesterol, C Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR), Rheumatoid Factor (RF), and Anti-CCP, were assessed in each group. The results revealed a significant improvement in these biomarkers in the high-dose purslane-supplemented group (300 mg/kg body weight) compared to the induced arthritis-high-fat-diet group. This suggests a potential protective role of purslane against arthritis associated with obesity, likely attributed to its lipolytic capacity and anti-inflammatory properties. These findings contribute to our understanding of the interplay between obesity, arthritis, and natural interventions, providing valuable insights for future therapeutic approaches.

中文翻译：

---

马齿苋提取物对实验诱发的肥胖相关关节炎的可能保护作用的生化评价

关节炎是一种常见的炎症性疾病，通常与肥胖有关。本研究旨在评估马齿苋提取物对诱发关节炎和肥胖的雄性白化大鼠的潜在保护作用。将 50 只大鼠随机分为 5 组：对照组、诱发关节炎高脂饮食组、高剂量马齿苋提取物补充组（300 mg/kg 体重）8 周、低剂量马齿苋提取物组-补充组（150毫克/公斤体重）8周，以及补充二甲双胍组。使用弗氏完全佐剂诱导大鼠关节炎。每组均评估血浆生物标志物，包括总胆固醇、甘油三酯、HDL-胆固醇、LDL-胆固醇、C反应蛋白（CRP）、红细胞沉降率（ESR）、类风湿因子（RF）和抗CCP。结果显示，与诱导关节炎高脂肪饮食组相比，高剂量马齿苋补充组（300 毫克/千克体重）的这些生物标志物有显着改善。这表明马齿苋对与肥胖相关的关节炎具有潜在的保护作用，这可能归因于其脂解能力和抗炎特性。这些发现有助于我们了解肥胖、关节炎和自然干预措施之间的相互作用，为未来的治疗方法提供有价值的见解。