This study aimed to investigate the association between changes in body composition, glycated hemoglobin, and lipid ratio during the treatment of patients with type 2 diabetes mellitus (T2DM). This retrospective analysis used data from outpatients with T2DM who had confirmed body composition and measured laboratories at administration and after treatment. The baseline characteristics and prescribed treatment were collected. The total cholesterol/high-density lipoprotein cholesterol (HDL) ratio, low-density lipoprotein cholesterol (LDL)/HDL ratio, and triglyceride–glucose (TyG) index were also calculated. A total of 207 patients (mean patient age, 62.0 ± 13.7 years; 68.1 % males) were enrolled. Fat mass index (FMI) changes correlated with the changes in the lipid ratio, whereas skeletal muscle mass index (SMI) changes inversely correlated with glycated hemoglobin (HbA1c) changes. Multiple regression analysis showed that changes in LDL/HDL and TyG correlated with FMI changes (t = 2.388, p = 0.017, t = 2.022, p = 0.044). Conversely, HbA1c changes correlated with SMI changes (t = −2.552, p = 0.011). In patients with T2DM, increased SMI was involved in glycemic efficacy, and FMI changes were associated with LDL/HDL and TyG.

中文翻译：

---

骨骼肌质量指数的增加与糖尿病治疗后的血糖疗效有关，脂肪质量指数的变化与 2 型糖尿病中血脂比的变化相关

本研究旨在探讨 2 型糖尿病 (T2DM) 患者治疗期间身体成分、糖化血红蛋白和脂质比率变化之间的关联。这项回顾性分析使用了 2 型糖尿病门诊患者的数据，这些患者在给药时和治疗后确认了身体成分并进行了实验室测量。收集基线特征和处方治疗。还计算了总胆固醇/高密度脂蛋白胆固醇（HDL）比值、低密度脂蛋白胆固醇（LDL）/HDL比值和甘油三酯-葡萄糖（TyG）指数。共有 207 名患者（患者平均年龄，62.0 ± 13.7 岁；68.1% 为男性）入组。脂肪质量指数（FMI）的变化与脂质比率的变化相关，而骨骼肌质量指数（SMI）的变化与糖化血红蛋白（HbA1c）的变化呈负相关。多元回归分析显示，LDL/HDL 和 TyG 的变化与 FMI 变化相关（t = 2.388，p = 0.017，t = 2.022，p = 0.044）。相反，HbA1c 变化与 SMI 变化相关 (t = −2.552，p = 0.011)。在 T2DM 患者中，SMI 增加与血糖疗效有关，FMI 变化与 LDL/HDL 和 TyG 相关。