Chemotherapy, pelvic radiotherapy (including total body irradiation) and novel compounds used to treat children and teenagers with benign or malignant diseases can lead to impaired fertility. For prepubertal female patients at high risk of treatment-related infertility, upfront storage of ovarian tissue is increasingly being recognised as standard of care. No surgical guidelines exist to ensure best practice technique. We reviewed current UK practice to assess surgical management. A ten-item, anonymous multiple-choice survey was distributed to the lead surgeons in all paediatric centres in England/Wales undertaking ovarian procurement for cryopreservation. There are currently 18 centres in England and Wales that provide ovarian procurement for cryopreservation. Responses were received from 100% of the invited paediatric surgical oncology centres in England and Wales. This national survey shows significant heterogeneity in the surgical management of ovarian procurement for cryopreservation. To ensure best outcomes, research into the various surgical methods is necessary to provide data for a standardised best practice approach. This is a level II evidence study. In itself, it is a national survey of specialists, which was undertaken in a prospective manner.

中文翻译：

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用于保留儿童生育能力的卵巢组织采集：需要标准化的手术实践指南

化疗、盆腔放疗（包括全身照射）和用于治疗患有良性或恶性疾病的儿童和青少年的新型化合物可能会导致生育能力受损。对于治疗相关不孕症高风险的青春期前女性患者，卵巢组织的预先储存越来越被认为是护理标准。不存在确保最佳实践技术的手术指南。我们回顾了英国当前的实践来评估手术管理。一项包含十项的匿名多项选择调查已分发给英格兰/威尔士所有儿科中心的主要外科医生，这些中心进行卵巢采购以进行冷冻保存。目前英格兰和威尔士有 18 个中心提供用于冷冻保存的卵巢采购。英格兰和威尔士 100% 受邀的儿科肿瘤外科中心都收到了回复。这项全国性调查显示，用于冷冻保存的卵巢获取手术管理存在显着的异质性。为了确保最佳结果，有必要对各种手术方法进行研究，以便为标准化最佳实践方法提供数据。这是一项 II 级证据研究。就其本身而言，这是一项以前瞻性方式进行的全国性专家调查。