Polycystic Ovary Syndrome (PCOS), a multifaceted endocrine disorder, affects a significant proportion of women globally, with its etiology rooted in both genetic and environmental factors. This study delves into the environmental aspect, particularly focusing on the role of endocrine-disrupting chemicals (EDCs) in the context of urbanization and industrialization. This research examines the impact of endocrine-disrupting chemicals (EDCs) — Bisphenol A (BPA), Mono-ethyl Hexyl Phthalate (MEHP), and Di-ethyl Hexyl Phthalate (DEHP) — on 40 women with Polycystic Ovary Syndrome (PCOS) across urban and rural Gujarat. Employing High-Performance Liquid Chromatography (HPLC) and chemiluminescence, we analyzed their blood samples for EDCs levels and hormonal parameters. Urban individuals displayed significantly higher BPA and DEHP concentrations, highlighting the environmental exposure differences. Notably, urban exposure to MEHP and DEHP correlated with a marked decrease in estradiol levels, while rural DEHP exposure was associated with an increase in estradiol but a decrease in prolactin and DHEAS levels. These findings illuminate the variable effects of EDC exposure on hormonal profiles in PCOS, influenced by geographical and environmental contexts. The study underscores the critical need for tailored environmental health policies to mitigate the diverse impacts of EDCs, advocating for a nuanced approach to PCOS management that considers environmental exposures. Our insights contribute to the understanding of PCOS’s hormonal dynamics, emphasizing the significance of addressing EDC exposure in different settings.

中文翻译：

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多囊卵巢综合症女性的内分泌干扰化学物质和荷尔蒙特征：城乡环境的比较研究

多囊卵巢综合症（PCOS）是一种多方面的内分泌疾病，影响着全球很大一部分女性，其病因根源于遗传和环境因素。这项研究深入探讨了环境方面，特别关注内分泌干扰化学品（EDC）在城市化和工业化背景下的作用。这项研究调查了内分泌干扰化学物质 (EDC)——双酚 A (BPA)、邻苯二甲酸单乙基己酯 (MEHP) 和邻苯二甲酸二乙基己酯 (DEHP) 对 40 名患有多囊卵巢综合症 (PCOS) 的女性的影响古吉拉特邦的城市和乡村。我们采用高效液相色谱 (HPLC) 和化学发光技术分析了他们的血液样本中的 EDC 水平和激素参数。城市个体的 BPA 和 DEHP 浓度显着较高，凸显了环境暴露差异。值得注意的是，城市暴露于 MEHP 和 DEHP 与雌二醇水平显着下降相关，而农村 DEHP 暴露则与雌二醇增加但催乳素和 DHEAS 水平下降相关。这些发现阐明了 EDC 暴露对 PCOS 患者荷尔蒙分布的不同影响，受地理和环境背景的影响。该研究强调迫切需要制定量身定制的环境健康政策，以减轻 EDC 的多种影响，并倡导对 PCOS 管理采取细致入微的方法，考虑环境暴露。我们的见解有助于理解 PCOS 的荷尔蒙动态，强调解决不同环境中 EDC 暴露问题的重要性。