Prochloraz is an extensively used imidazole fungicide in agriculture, but low water solubility limits its application. In the present study, inclusion complex nanofibers of prochloraz and Hydroxypropyl--Cyclodextrin (prochloraz/HPCD-IC-NF) were prepared by electrospinning method. The results of various characterization experiments indicated that prochloraz was effectively encapsulated in the cyclodextrin cavity to form inclusion complex nanofibers. Phase solubility study demonstrated that HPCD had a significant solubilization effect on prochloraz. In 10 mM HPCD solution, the solubility of prochloraz was increased about 2.68 times. Thermogravimetric analysis experiments indicated the beginning thermos-decomposed temperature of prochloraz in prochloraz/HPγCD-IC-NF was raised by 31℃ (from 281℃ to 312℃). The molecular simulation visually showed the best state and the most stable model of prochloraz entering the cyclodextrin cavity. In addition, the fungal inhibitory activity of prochloraz/HPCD-IC-NF against was 4.559 times to that of prochloraz. In conclusion, the preparation of inclusion nanofibers can improve the water solubility, thermal stability and antifungal activity of mimosine, which has the potential to reduce environmental damage in agricultural applications.

中文翻译：

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静电纺丝制备咪鲜胺/羟丙基-γ-环糊精包合物的抗真菌纳米纤维

咪鲜胺是一种在农业上广泛使用的咪唑类杀菌剂，但水溶性较低限制了其应用。本研究采用静电纺丝法制备了咪鲜胺和羟丙基环糊精包合物纳米纤维（咪鲜胺/HPCD-IC-NF）。各种表征实验的结果表明咪鲜胺被有效地封装在环糊精空腔中形成包合物纳米纤维。相溶解度研究表明HPCD对咪鲜胺具有显着的增溶作用。在10 mM HPCD溶液中，咪鲜胺的溶解度增加约2.68倍。热重分析实验表明，咪鲜胺/HPγCD-IC-NF中咪鲜胺的起始热分解温度提高了31℃（从281℃提高到312℃）。分子模拟直观地展示了咪鲜胺进入环糊精腔的最佳状态和最稳定的模型。此外，咪鲜胺/HPCD-IC-NF对真菌的抑制活性是咪鲜胺的4.559倍。总之，包合物纳米纤维的制备可以提高含羞草碱的水溶性、热稳定性和抗真菌活性，有可能减少农业应用中的环境破坏。