The symptoms of pediatric bipolar disorder (PBD)-I and PBD-II differ, but accurate identification at an early stage is difficult and may prevent effective treatment of this disorder. Therefore, it is urgent to elucidate a biological marker based on objective imaging indicators to help distinguish the two. Therefore, this research aims to compare the functional connectivity between PBD-I patient and PBD-II patient in different brain networks. Our study enrolled 31 PBD-I and 23 PBD-II patients from 12 to 17 years of age. They were analyzed by resting state-functional connectivity through Independent component analysis (ICA). We found differences between PBD-I and PBD-II in functional connectivity of the default network, frontoparietal network, salience network and limbic system. In addition, the clinical features, cognitive functions are associated with the functional connectivity of the intrinsic networks in PBD-I and PBD-II separately. This research is the first to find differences in functional connectivity between PBD-I and PBD-II, suggesting that abnormality of the functional connectivity within large networks may be biomarkers that help differentiate PBD-I from PBD-II in the future.

中文翻译：

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青少年双相 I 型与双相 II 型障碍的内在网络功能连接异常

小儿双相情感障碍 (PBD)-I 和 PBD-II 的症状有所不同，但早期准确识别很困难，并且可能妨碍对该疾病的有效治疗。因此，迫切需要阐明一种基于客观影像指标的生物标志物来帮助区分两者。因此，本研究旨在比较PBD-I患者和PBD-II患者不同大脑网络的功能连接。我们的研究招募了 31 名 12 至 17 岁的 PBD-I 和 23 名 PBD-II 患者。通过独立成分分析 (ICA)，通过静息状态功能连接对它们进行分析。我们发现PBD-I和PBD-II在默认网络、额顶网络、显着网络和边缘系统的功能连接方面存在差异。此外，PBD-I和PBD-II的临床特征、认知功能分别与内在网络的功能连接相关。该研究首次发现PBD-I和PBD-II之间功能连接的差异，表明大网络内功能连接的异常可能是未来帮助区分PBD-I和PBD-II的生物标志物。