Non-alcoholic steatohepatitis (NASH) is a pathogenic stage of the broader non-alcoholic fatty liver disease (NAFLD). Histological presentation of NASH includes hepatocyte ballooning, macrophage polarization, ductular reaction, and hepatic stellate cell (HSCs) activation. At a cellular level, a heterogenous population of cells such as hepatocytes, macrophages, cholangiocytes, and HSCs undergo dramatic intra-cellular changes in response to extracellular triggers, which are termed “cellular plasticity. This dynamic switch in the cellular structure and function of hepatic parenchymal and non-parenchymal cells and their crosstalk culminates in the perpetuation of inflammation and fibrosis in NASH. This review presents an overview of our current understanding of cellular plasticity in NASH and its molecular mechanisms, along with possible targeting to develop cell-specific NASH therapies.

中文翻译：

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非酒精性脂肪性肝炎（NASH）细胞可塑性的动态

非酒精性脂肪性肝炎 (NASH) 是更广泛的非酒精性脂肪肝病 (NAFLD) 的一个致病阶段。NASH 的组织学表现包括肝细胞气球样变、巨噬细胞极化、导管反应和肝星状细胞 (HSC) 激活。在细胞水平上，肝细胞、巨噬细胞、胆管细胞和造血干细胞等异质细胞群响应细胞外触发因素而发生剧烈的细胞内变化，这被称为“细胞可塑性”。肝实质和非实质细胞的细胞结构和功能的这种动态转换及其串扰最终导致 NASH 中炎症和纤维化的持续存在。这篇综述概述了我们目前对 NASH 细胞可塑性及​​其分子机制的理解，以及开发细胞特异性 NASH 疗法的可能目标。