This study aimed to explore the incidence and severity of vincristine-induced peripheral neuropathy (VIPN) in non-Hodgkin lymphoma (NHL) survivors (primary aim) and its impact on daily life by comparing common cancer symptoms, functional status, and quality of life (QoL) among survivors with acute, long-term, and non-VIPN (secondary aim). This cross-sectional study examined 144 NHL survivors. Standardized questionnaires were used to assess common cancer symptoms, functional status, and QoL with the European Organization for the Research and Treatment of Cancer - Quality of Life Questionnaire (EORTC-QLQ-C30). VIPN (Chemotherapy-Induced Peripheral Neuropathy) status was classified using EORTC-QLQ-CIPN20. A self-designed interference scale was developed to determine the impact of the VIPN on daily activities. The Kruskal–Wallis test and Spearman rank correlation were used in this study. Among the survivors of acute and long-term VIPN, the highest incidences and most severe symptoms were found for hand numbness and foot cramps. A significant moderate correlation was found between disturbances in daily activities and acute or long-term VIPN, including gait changes, going up or down the stairs, and imbalance-related falls. Acute and long-term VIPN survivors showed worse symptoms (fatigue, insomnia, and constipation) and lower QoL than non-VIPN survivors did. In acute VIPN, social function was significantly affected, whereas in long-term VIPN, emotional and cognitive functions were affected. Numbness and cramps should be addressed in survivors of acute and long-term VIPN. Preventing falls is recommended for NHL survivors with VIPN, and psychological support is suggested for long-term VIPN survivors.

中文翻译：

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非霍奇金淋巴瘤幸存者中急性、长期或非长春新碱引起的周围神经病变：症状、日常活动、功能状态和生活质量

本研究旨在通过比较常见的癌症症状、功能状态和生活质量，探讨非霍奇金淋巴瘤 (NHL) 幸存者长春新碱诱发的周围神经病变 (VIPN) 的发生率和严重程度（主要目的）及其对日常生活的影响急性、长期和非 VIPN 幸存者的生活质量 (QoL)（次要目标）。这项横断面研究调查了 144 名 NHL 幸存者。欧洲癌症研究与治疗组织 - 生活质量问卷 (EORTC-QLQ-C30) 使用标准化问卷来评估常见癌症症状、功能状态和生活质量。 VIPN（化疗引起的周围神经病变）状态使用 EORTC-QLQ-CIPN20 进行分类。我们开发了自行设计的干扰量表来确定 VIPN 对日常活动的影响。本研究使用了 Kruskal-Wallis 检验和 Spearman 等级相关。在急性和长期VIPN的幸存者中，手部麻木和足部抽筋的发生率最高且症状最严重。日常活动障碍与急性或长期 VIPN 之间存在显着的中度相关性，包括步态变化、上下楼梯以及与不平衡相关的跌倒。与非 VIPN 幸存者相比，急性和长期 VIPN 幸存者表现出更严重的症状（疲劳、失眠和便秘）和更低的生活质量。在急性VIPN中，社会功能受到显着影响，而在长期VIPN中，情绪和认知功能受到影响。急性和长期 VIPN 幸存者的麻木和痉挛应该得到解决。建议接受 VIPN 的 NHL 幸存者预防跌倒，并建议长期 VIPN 幸存者提供心理支持。