Objectives: We aimed to assess health-related quality of life (HRQOL) in a cohort of very preterm born children and adolescents (aged 5-16), and to compare it with their fullterm born siblings and the general population. We also explored correlates of HRQOL among the very preterm born. Methods: Cross-sectional survey. Primary outcome was KINDL total score (0 worst - 100 best). Linear mixed models accounted for family unit. Secondary analysis compared very preterm born children to another cohort of healthy children from the same time period. A classification tree analysis explored potential correlates of HRQOL. Results: On average, preterm children had a 2.1 point lower KINDL total score than fullterm sibling controls (95% CI -3.6 to -0.6). Compared to population controls, very preterm born children had a 1.4 point higher KINDL score (0.2 to 2.5). Chronic health conditions, age, and respiratory symptoms affecting daily life were key correlates of HRQOL among very preterm born children. Conclusions: Very preterm birth in children and adolescents was not associated with a relevant reduction in HRQOL compared to their fullterm born peers. However, lower HRQOL was likely explained by other factors, such as older age, the presence of chronic health conditions, but also by current respiratory symptoms that may be modifiable. A comprehensive assessment of the pulmonary sequelae provoking symptoms and interventions targeting medical management, physical activity and exercise capacity of preterm born children and adolescents may help to reduce respiratory symptoms and its potential influence on HRQOL needs to be investigated further.

中文翻译：

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极早产儿童和青少年的健康相关生活质量及其相关因素

目的：我们旨在评估一组极早产儿童和青少年（5-16 岁）的健康相关生活质量 (HRQOL)，并将其与他们的足月出生的兄弟姐妹和一般人群进行比较。我们还探讨了早产儿 HRQOL 的相关性。方法：横断面调查。主要结果是 KINDL 总分（0 最差 - 100 最好）。线性混合模型占家庭单位。二次分析将极早产儿与同一时期的另一组健康儿童进行了比较。分类树分析探讨了 HRQOL 的潜在相关性。结果：平均而言，早产儿的 KINDL 总分比足月兄弟姐妹对照低 2.1 分（95% CI -3.6 至 -0.6）。与对照组相比，极早产儿的 KINDL 评分高出 1.4 分（0.2 至 2.5）。慢性健康状况、年龄和影响日常生活的呼吸道症状是早产儿 HRQOL 的关键相关因素。结论：与足月出生的同龄人相比，儿童和青少年的严重早产与 HRQOL 的相关降低无关。然而，HRQOL 较低可能是由其他因素解释的，例如年龄较大、慢性健康状况的存在，以及当前可能可以改变的呼吸道症状。对引起症状的肺部后遗症进行全面评估，并针对早产儿和青少年的医疗管理、体力活动和运动能力进行干预可能有助于减轻呼吸道症状，其对 HRQOL 的潜在影响需要进一步研究。