The effect of subthalamic nucleus (STN) deep brain stimulation (DBS) on urinary dysfunction and constipation in Parkinson’s disease (PD) is variable. This study aimed to identify potential surgical and nonsurgical variables predictive of these outcomes.

The authors used the Movement Disorder Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Part I to assess urinary dysfunction (item 10) and constipation (item 11) preoperatively and at 6–12 months postoperatively. A multiple linear regression model was used to investigate the impact of global cerebral atrophy (GCA) and active electrode contact location on the urinary dysfunction and constipation follow-up scores, controlling for age, disease duration, baseline score, motor improvement, and levodopa-equivalent dose changes. An electric field model was applied to localize the maximal-effect sites for constipation and urinary dysfunction compared with those for motor improvement.

Among 74 patients, 23 improved, 28 deteriorated, and 23 remained unchanged for urinary dysfunction; 25 improved, 15 deteriorated, and 34 remained unchanged for constipation. GCA score and age significantly predicted urinary dysfunction follow-up score (R² = 0.36, p < 0.001). Increased GCA and age were independently associated with worsening urinary symptoms. Disease duration, baseline constipation score, and anterior active electrode contacts in both hemispheres were significant predictors of constipation follow-up score (R² = 0.31, p < 0.001). Higher baseline constipation score and disease duration were associated with worsening constipation; anterior active contact location was associated with improvement in constipation.

Anterior active contact location was associated with improvement in constipation in PD patients after STN DBS. PD patients with greater GCA scores before surgery were more likely to experience urinary deterioration after DBS.

丘脑底核 (STN) 深部脑刺激 (DBS) 对帕金森病 (PD) 尿功能障碍和便秘的影响是可变的。本研究旨在确定预测这些结果的潜在手术和非手术变量。

作者使用运动障碍协会-统一帕金森病评定量表 (MDS-UPDRS) 第 I 部分来评估术前和术后 6-12 个月的排尿功能障碍（第 10 项）和便秘（第 11 项）。使用多元线性回归模型来研究全脑萎缩（GCA）和主动电极接触位置对排尿功能障碍和便秘随访评分的影响，控制年龄、病程、基线评分、运动改善和左旋多巴。当量剂量变化。应用电场模型来定位便秘和泌尿功能障碍与运动改善的最大效果部位。

74 例患者中，23 例改善，28 例恶化，23 例尿功能障碍保持不变；25 人改善，15 人恶化，34 人便秘没有变化。GCA 评分和年龄显着预测尿功能障碍随访评分（R ² = 0.36，p < 0.001）。GCA 增加和年龄与泌尿系统症状恶化独立相关。疾病持续时间、基线便秘评分和两个半球的前主动电极接触是便秘随访评分的显着预测因素（R ² = 0.31，p < 0.001）。较高的基线便秘评分和疾病持续时间与便秘恶化相关；前主动接触位置与便秘的改善相关。

前主动接触位置与 STN DBS 后 PD 患者便秘的改善相关。术前 GCA 评分较高的 PD 患者在 DBS 后更有可能出现尿路恶化。