Among U.S. adults at risk for severe COVID-19 in Epic Cosmos, the lowest rate of hospitalization was among those receiving three or more mRNA vaccine doses and nirmatrelvir-ritonavir (aHR 0.22, 95%CI: 0.19–0.24). Adults who are at high-risk of severe COVID-19 disease, including vaccinated persons, should be considered for antiviral treatment.

中文翻译：

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疫苗接种和尼马瑞韦-利托那韦联合保护成人 COVID-19 免于住院

在 Epic Cosmos 中面临严重 COVID-19 风险的美国成年人中，住院率最低的是接受三剂或以上 mRNA 疫苗和尼尔马瑞韦-利托那韦的患者（aHR 0.22，95%CI：0.19-0.24）。患有严重 COVID-19 疾病高风险的成年人，包括接种疫苗的人，应考虑接受抗病毒治疗。