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Specific IgA, But Not IgG, in Human Milk From COVID-19-infected Mothers Neutralizes SARS-CoV-2.
The Pediatric Infectious Disease Journal ( IF 3.6 ) Pub Date : 2024-02-29 , DOI: 10.1097/inf.0000000000004291
Patricia Macchiaverni 1, 2 , Megan Lloyd 1, 2, 3 , Laura Masters 3 , Nivedithaa Divakara 1, 2 , Kritu Panta 3 , Allison Imrie 3 , Laura Sánchez-García 4 , Adelina Pellicer 4 , Juan M. Rodriguez 5 , Valerie Verhasselt 1, 2
Affiliation  

This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity of human milk against COVID-19 was found in colostrum from infected mothers. Neutralizing activity was associated with high levels of specific IgA. Depletion of IgA, but not IgG, from milk samples completely abolished the ability of human milk to neutralize severe acute respiratory syndrome coronavirus 2.

中文翻译:

感染 COVID-19 的母亲的母乳中的特异性 IgA(而非 IgG)可以中和 SARS-CoV-2。

这项研究强调了母乳在为新生儿提供抗严重急性呼吸综合征冠状病毒 2 免疫力方面的重要性。在受感染母亲的初乳中发现了母乳对 COVID-19 的最高保护活性。中和活性与高水平的特异性 IgA 相关。牛奶样本中 IgA(而非 IgG)的消耗完全消除了母乳中和严重急性呼吸综合征冠状病毒 2 的能力。
更新日期:2024-02-29
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