Autotaxin (ATX) produces lysophosphatidic acid (LPA), which directly promotes pancreatic ductal adenocarcinoma (PDAC) growth, but the role of the tumor microenvironment (TME) in ATX-driven tumor growth is unclear. ATX–LPA signaling in PDAC is now shown to shape the TME by inhibiting eosinophil recruitment, resulting in increased tumor growth.

中文翻译：

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ATX 限制抗肿瘤嗜酸性粒细胞反应

自分泌运动因子（ATX）产生溶血磷脂酸（LPA），直接促进胰腺导管腺癌（PDAC）生长，但肿瘤微环境（TME）在ATX驱动的肿瘤生长中的作用尚不清楚。现在显示 PDAC 中的 ATX-LPA 信号传导通过抑制嗜酸性粒细胞募集来塑造 TME，从而导致肿瘤生长增加。