Abstract

Objectives: This study examined blood brain natriuretic peptide (BNP) concentrations in newly diagnosed primary hyperthyroidism (PHT) patients, compared them to healthy controls, and examined their correlation with age, gender, and biochemical variables triiodothyronine (T3), tetraiodothyronine (T4), and thyroid stimulating hormone (TSH). The study also sought out a BNP limit for primary hyperthyroidism. Design and methods: The present study included 45 PHT patients without thyroid medication, heart failure, acute coronary syndrome, hypertension, renal failure, pregnancy, Cushing’s syndrome, liver disease, and obesity. In addition, 90 subjects served as the control group in the study. Patients’ and controls’ blood sera were used to measure the concentrations of T3, T4, and TSH by ELFA and BNP by ELISA. Results: The group with PHT had significantly higher BNP levels than the control group. BNP exhibited a significant positive correlation with T3 levels and with age in the PHT group, and its level was higher in females. BNP demonstrated a perfect area under the curve (AU C) where the optimal cutoff value was >32.17, with high sensitivity and specificity. Conclusions: PHT influences BNP levels, potentially reflecting disease presence and severity or thyroid-related complications. BNP levels increase with age, with female patients having higher mean levels. A cutoff value can aid clinicians in diagnosing and managing PHT, guiding evaluation and treatment decisions. Further research is needed to substantiate findings and investigate the underlying mechanisms of BNP’s role in thyroid dysfunction.

中文翻译：

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无心脏病初诊甲亢患者脑钠肽水平分析

摘要

目的：本研究检查了新诊断的原发性甲状腺功能亢进症 (PHT) 患者的血脑钠肽 (BNP) 浓度，将其与健康对照进行比较，并检查其与年龄、性别和生化变量三碘甲状腺原氨酸 (T3)、四碘甲状腺原氨酸 (T4) 的相关性和促甲状腺激素（TSH）。该研究还找出了原发性甲状腺功能亢进症的 BNP 限值。设计和方法：本研究包括 45 名未服用甲状腺药物、心力衰竭、急性冠状动脉综合征、高血压、肾衰竭、妊娠、库欣综合征、肝病和肥胖的 PHT 患者。此外，90名受试者作为研究中的对照组。患者和对照者的血清用于通过ELFA测量T3、T4和TSH的浓度，通过ELISA测量BNP的浓度。结果：PHT组BNP水平显着高于对照组。PHT组BNP与T3水平和年龄呈显着正相关，且女性中BNP水平较高。BNP 表现出完美的曲线下面积 (AU C)，其中最佳截止值 >32.17，具有高灵敏度和特异性。结论：PHT 影响 BNP 水平，可能反映疾病的存在和严重程度或甲状腺相关并发症。BNP 水平随着年龄的增长而增加，女性患者的平均水平更高。临界值可以帮助临床医生诊断和管理 PHT，指导评估和治疗决策。需要进一步的研究来证实研究结果并调查 BNP 在甲状腺功能障碍中的作用的潜在机制。