BackgroundLipid metabolism related factors, such as angiopoietin‐like protein 3 (ANGPTL3), angiopoietin‐like 4 (ANGPTL4), fatty acid‐binding protein 4 (FABP4) are newly discovered factors that can affect coronary artery disease (CAD). In this study, we aimed to investigate the relationship between CAD and these lipid metabolism factors.HypothesisANGPTL3, ANGPTL4, and FABP4 may provide a new method for the control of CAD risk factors and the prevention and treatment of CAD.MethodsWe enrolled 284 consecutive inpatients with suspected CAD and divided them into CAD and non‐CAD groups based on the coronary angiography results. Serum ANGPTL3, ANGPTL4, FABP4, and tumor necrosis factor‐α (TNF‐α) levels were estimated using the enzyme‐linked immunosorbent assay. Multivariate logistic regression was used to assess the risk factors for CAD. The receiver operating characteristic curve was used to determine the cutoff and diagnostic values.ResultsThe serum TNF‐α, FABP4, ANGPTL3, and ANGPTL4 values showed a significant difference between the CAD and non‐CAD groups (p < .05). After adjusting for confounding factors, the FABP4, ANGPTL3, and ANGPTL4 levels were independently associated with CAD (p < .05). The ANGPTL3 expression level was an independent risk factor for CAD in patients with hypertension, but not in those without hypertension. The ANGPTL3 > 67.53 ng/mL, ANGPTL4 > 29.95 ng/mL, and FABP4 > 1421.25 ng/L combination had the highest diagnostic value for CAD.ConclusionANGPTL3, ANGPTL4, and FABP4 were identified as independent risk factors for CAD and have valuable clinical implications for the diagnosis and treatment of CAD.

中文翻译：

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血清FABP4、ANGPTL3、ANGPTL4水平与冠心病的相关性

背景脂质代谢相关因子，如血管生成素样蛋白3（ANGPTL3）、血管生成素样4（ANGPTL4）、脂肪酸结合蛋白4（FABP4）是新发现的影响冠状动脉疾病（CAD）的因素。本研究旨在探讨CAD与这些脂质代谢因素之间的关系。假设ANGPTL3、ANGPTL4和FABP4可能为控制CAD危险因素和预防和治疗CAD提供新的方法。方法我们连续入组284例患有冠心病的住院患者。怀疑患有 CAD 的患者，根据冠状动脉造影结果将其分为 CAD 组和非 CAD 组。使用酶联免疫吸附测定法评估血清 ANGPTL3、ANGPTL4、FABP4 和肿瘤坏死因子-α (TNF-α) 水平。多变量逻辑回归用于评估 CAD 的危险因素。使用受试者工作特征曲线来确定截止值和诊断值。 结果 CAD 组和非 CAD 组之间血清 TNF-α、FABP4、ANGPTL3 和 ANGPTL4 值显示出显着差异（p< .05)。调整混杂因素后，FABP4、ANGPTL3 和 ANGPTL4 水平与 CAD 独立相关（p< .05)。ANGPTL3表达水平是高血压患者发生CAD的独立危险因素，但对于非高血压患者则不是。ANGPTL3 > 67.53 ng/mL、ANGPTL4 > 29.95 ng/mL、FABP4 > 1421.25 ng/L 组合对 CAD 的诊断价值最高。结论 ANGPTL3、ANGPTL4 和 FABP4 被确定为 CAD 的独立危险因素，具有有价值的临床意义。用于 CAD 的诊断和治疗。