Cellular therapies, including autologous stem cell transplant (ASCT), allogeneic hematopoietic cell transplantation (alloHCT), and chimeric antigen receptor- (CAR-) T cell therapies are essential treatment modalities for many hematological malignancies. Although their use in older adults has substantially increased within the past decades, cellular therapies represent intensive treatment approaches that exclude a large percentage of older adults due to comorbidities and frailty. Under- and overtreatment in older adults with hematologic malignancy is a challenge and many treatment decisions are influenced by chronologic age.

中文翻译：

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患有血液系统恶性肿瘤的老年人的细胞疗法：基于病例的最新综述

细胞疗法，包括自体干细胞移植 (ASCT)、同种异体造血细胞移植 (alloHCT) 和嵌合抗原受体 (CAR-) T 细胞疗法，是许多血液恶性肿瘤的重要治疗方式。尽管过去几十年细胞疗法在老年人中的使用大幅增加，但细胞疗法代表了强化治疗方法，由于合并症和虚弱而排除了很大一部分老年人。患有血液系统恶性肿瘤的老年人的治疗不足和过度治疗是一个挑战，许多治疗决策都受到实际年龄的影响。