BackgroundMechanical thrombectomy (MT) is a safe and effective treatment option for acute ischemic stroke due to large vessel occlusion. To investigate differences in outcomes between patients receiving left-sided and right-sided MT, we performed a systematic review and meta-analysis.MethodsA systematic literature review was performed using Embase, PubMed, Scopus, and Web of Science databases. Additional literature was searched for manually. Studies reporting safety and efficacy metrics for MT were included. Data regarding the modified Rankin scale (mRS), thrombolysis in cerebral infarction (TICI), symptomatic intracranial hemorrhage (sICH), and 90-day mortality were included. A random-effects model was used to calculate pooled odds ratios (ORs), mean differences (MDs), and 95% confidence intervals (CIs).ResultsThe literature search yielded 13 reports consisting of 19 studies ranging from 98 to 5590 patients. Patients presenting with left-sided stroke had a National Institutes of health stroke scale score 2.89 greater than patients presenting with right-sided stroke (MD = 2.89; 95% CI = 2.09–3.68; P-value < 0.001). There were no differences between left-sided and right-sided MT patients for mRS 0–2 (OR = 0.94; 95% CI = 0.85–1.04; P-value = 0.224), TICI 2b–3 (OR = 1.05; 95% CI = 0.88–1.25; P-value = 0.598), sICH (OR = 0.83; 95% CI = 0.61–1.14; P-value = 0.255), or 90-day mortality (OR = 1.06; 95% CI = 0.84–1.33; P-value = 0.610).ConclusionsThere does not appear to be a difference in outcomes for patients undergoing left-sided or right-sided thrombectomy.

中文翻译：

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急性缺血性卒中左侧和右侧机械血栓切除术的结果差异：系统评价和荟萃分析

背景机械血栓切除术（MT）是大血管闭塞引起的急性缺血性脑卒中安全有效的治疗选择。为了调查接受左侧和右侧 MT 的患者的结果差异，我们进行了系统回顾和荟萃分析。方法使用 Embase、PubMed、Scopus 和 Web of Science 数据库进行系统文献回顾。手动搜索其他文献。报告 MT 安全性和有效性指标的研究也包括在内。包括有关改良 Rankin 量表 (mRS)、脑梗塞溶栓 (TICI)、症状性颅内出血 (sICH) 和 90 天死亡率的数据。使用随机效应模型来计算合并比值比 (OR)、平均差 (MD) 和 95% 置信区间 (CI)。结果 文献检索产生了 13 份报告，其中包括 19 项研究，涵盖 98 至 5590 名患者。左侧卒中患者的美国国立卫生研究院卒中量表评分比右侧卒中患者高 2.89（MD = 2.89；95% CI = 2.09–3.68；P 值 < 0.001）。左侧和右侧 MT 患者的 mRS 0–2（OR = 0.94；95% CI = 0.85–1.04；P 值 = 0.224）、TICI 2b–3（OR = 1.05；95% CI = 0.88–1.25；P 值 = 0.598）、sICH（OR = 0.83；95% CI = 0.61–1.14；P 值 = 0.255）或 90 天死亡率（OR = 1.06；95% CI = 0.84– 1.33；P 值 = 0.610）。结论 接受左侧或右侧血栓切除术的患者的结果似乎没有差异。