: An efficient synthesis of Chromeno[b]pyrimidine derivatives 4 has been achieved by treating 4-hydroxy-2H-chromen-2-one 1, furan-2-carbaldehyde / 1H-pyrrole-2-carbaldehyde/ thiophene-2- carbaldehyde 2, and urea/thiourea 3 at 65-70 °C for 90-120 min using 1-Ethyl-3-methylimidazolium acetate as ionic liquid and medium with good yields 86-90%. This synthetic method has numerous advantages, including high yields, a simple protocol, environmental friendliness, brief reaction times, and mild reaction conditions. Using a catalytically active ionic liquid as the medium eliminates the need for a catalyst and a solvent. In this study, the docking score of the synthesized compounds was found to be between -8 to -9 kcal/mol similar to the co-crystal. Additionally, the compounds maintained their amino acid interactions with Tyr 281 (coagulation protein; 6WV3) and Thr 179 (tubulin polymerization protein; 5LYJ.pdb).

中文翻译：

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[EMIM] [OAc]：一种用于合成新型 4-(呋喃/吡咯/噻吩-2-基)-3, 4-二氢-1H-色烯基 [4,3-d]嘧啶-2 的高效离子液体介质,5-二酮和分子对接研究

: 通过处理4-羟基-2H-chromen-2-one 1, 呋喃-2-甲醛/1H-吡咯-2-甲醛/噻吩-2-甲醛2，高效合成了Chromeno[b]嘧啶衍生物4和尿素/硫脲 3，使用 1-乙基-3-甲基咪唑乙酸盐作为离子液体和介质，在 65-70 °C 下反应 90-120 分钟，产率高达 86-90%。该合成方法具有收率高、流程简单、环境友好、反应时间短、反应条件温和等优点。使用催化活性离子液体作为介质无需催化剂和溶剂。在这项研究中，发现合成化合物的对接分数在-8至-9 kcal/mol之间，与共晶相似。此外，这些化合物保持了与 Tyr 281（凝血蛋白；6WV3）和 Thr 179（微管蛋白聚合蛋白；5LYJ.pdb）的氨基酸相互作用。