Epigenetic memory allows organisms to stably alter their transcriptional program in response to developmental or environmental stimuli. Such transcriptional programs are mediated by heritable regulation of the function of enhancers and promoters. Memory involves read–write systems that enable self-propagation and mitotic inheritance of acting epigenetic marks to induce stable changes in transcription. Also, in response to environmental cues, cells can induce epigenetic transcriptional memory to poise inducible genes for faster induction in the future. Here, we discuss modes of epigenetic inheritance and the molecular basis of epigenetic transcriptional memory.

中文翻译：

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表观遗传转录记忆的遗传

表观遗传记忆使生物体能够稳定地改变其转录程序以响应发育或环境刺激。这种转录程序是通过增强子和启动子功能的遗传调节来介导的。记忆涉及读写系统，该系统能够实现作用表观遗传标记的自我繁殖和有丝分裂遗传，从而诱导转录的稳定变化。此外，为了响应环境提示，细胞可以诱导表观遗传转录记忆，以平衡诱导基因，以便在未来更快地诱导。在这里，我们讨论表观遗传的模式和表观遗传转录记忆的分子基础。