Chemotherapy-induced peripheral neuropathy (CIPN) after curative treatment for testicular germ cell tumors (GCTs) has been previously reported. It has been shown that CIPN can contribute to impaired quality of life (QOL) in cancer survivors. Herein, we aimed to evaluate CIPN in association with QOL in GCT survivors. European Organization for Research and Treatment of Cancer (EORTC) Quality of Life - Chemotherapy-Induced Peripheral Neuropathy questionnaire (QLQ-CIPN20) and Quality of Life Questionnaire (QLQ-C30) were prospectively completed by GCT survivors ( = 151) at National Cancer Institute in Slovakia during their annual follow-up. The median follow-up was 10 years (range 4-30). Upon obtaining the scores from each questionnaire, each score from QLQ-C30 was correlated with CIPN defined as high or low (above and below median) as obtained from CIPN20. GCT survivors with high overall CIPN score reported impaired QOL in QLQ-C30. The global health status was lower in survivors with high CIPN versus low CIPN (mean score ± SEM: 67.17 ± 2.00 vs. 86.18 ± 1.76, < .00001). Survivors with high CIPN reported worse physical, role, emotional, cognitive, and social functioning compared to survivors with low CIPN (all < .00001). CIPN high survivors perceived more fatigue, nausea, pain, dyspnea, sleeping disorders, and appetite loss compared to CIPN low survivors (all < .004). Higher burden of CIPN was associated with more financial problems vs CIPN low (mean score ± SEM: 19.70 ± 2.64 vs. 6.67 ± 2.32, = .00025). Spearman analysis has confirmed negative correlation of overall CIPN20 score with QLQ-C30 global health status (R = −0.53, < .0001). CIPN is a strong predictor of impairment in QOL among GCT survivors. Molecular mechanisms of neurotoxicity should be intensively studied to find preventive and therapeutic strategies.

中文翻译：

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化疗引起的周围神经病变（CIPN）是睾丸生殖细胞肿瘤幸存者生活质量下降的预测因素

此前已有报道睾丸生殖细胞肿瘤（GCT）治愈后化疗引起的周围神经病变（CIPN）。研究表明，CIPN 可能会导致癌症幸存者的生活质量 (QOL) 受损。在此，我们的目的是评估 CIPN 与 GCT 幸存者生活质量的关系。欧洲癌症研究与治疗组织 (EORTC) 生活质量 - 化疗引起的周围神经病变问卷 (QLQ-CIPN20) 和生活质量问卷 (QLQ-C30) 由国家癌症研究所的 GCT 幸存者 (= 151) 前瞻性完成在斯洛伐克进行年度后续行动。中位随访时间为 10 年（范围 4-30）。在获得每份问卷的分数后，QLQ-C30 的每个分数都与 CIPN20 中获得的定义为高或低（高于和低于中位数）的 CIPN 相关。总体 CIPN 评分较高的 GCT 幸存者报告 QLQ-C30 的生活质量受损。高 CIPN 幸存者的总体健康状况低于低 CIPN 幸存者（平均评分 ± SEM：67.17 ± 2.00 与 86.18 ± 1.76，< .00001）。与低 CIPN 的幸存者相比，高 CIPN 的幸存者报告身体、角色、情绪、认知和社会功能较差（全部 < 0.00001）。与 CIPN 低幸存者相比，CIPN 高幸存者感到更多的疲劳、恶心、疼痛、呼吸困难、睡眠障碍和食欲不振（均 < 0.004）。与低 CIPN 相比，较高的 CIPN 负担与更多的财务问题相关（平均分 ± SEM：19.70 ± 2.64 与 6.67 ± 2.32，= .00025）。 Spearman 分析证实 CIPN20 总体评分与 QLQ-C30 全球健康状况呈负相关（R = -0.53，< .0001）。 CIPN 是 GCT 幸存者生活质量受损的有力预测因子。应深入研究神经毒性的分子机制，以找到预防和治疗策略。