In Texas and Southeastern United States Cu concentration in the soil is in the lower 50th percentile, this leads low bioavailability of copper for livestock. Therefore, a 70-d completely randomized block design study was conducted to determine the effects of Cu and fecal egg count in grazing beef cows (n = 40). Cows were blocked by parity and body weight (BW) then randomly assigned to 1 of 2 treatments: standard offering of copper via free choice mineral (CON; Ragland Sweet Mag Mineral Mix, 425 ppm Cu) and those receiving a 25 mg Cu rumen bolus in addition to the standard offering (Santa Cruz Animal Health, Dallas, TX). Cattle were managed as a single herd at the with equal access to water, a grain supplement, and a warm season grass pasture. Fecal samples via rectal grab, blood via coccygeal venipuncture, BW, BCS, hair coat (1 being the healthiest) and shedding (1 being the most slick) scores were all collected on d 0, 10, 24, 38, and 66 relative to treatment initiation. Sera were analyzed to determine circulating Cu, macrominerals, urea, creatinine, and various blood proteins. Fecal egg counts were conducted to determine Coccidial, Moniezia, and Trichostrongyle egg content. Data were analyzed using the GLIMMIX procedure of SAS 9.4 (SAS inst. Inc, Cary, NC). No treatment × day interaction (P = 0.988) was observed for circulating Cu; however, Cu decreased (P < 0.001) in all cattle over time, and TRT tended (P = 0.090) to have increased Cu compared with CON. No interactions or main effects occurred (P > 0.509) for BW. No interaction (P = 0.4389) occurred for BCS, hair, or shedding scores. Hair scores (P < 0.001), shedding scores (P < 0.041), and BCS(P < 0.001) decreased in all cattle over time. Body condition for TRT (5.2 ± 0.056) was greater (P =.0024) than CON (4.9 ± 0.057). Hair score by day decreased (P < 0.001) in TRT, while the shedding had a tendency of increasing (P = 0.0411) by TRT. There were no interactions or main effects on Coccidial (P < 0.220) or Trichostrongyle (P < 0.274) egg content. While no interaction (P = 0.673) for Moniezia was observed, TRT tended (P = 0.095) to have fewer Moniezia eggsthan CON. No interactions (P > 0.100) were observed for any of the blood metabolites, and while they differed (P < 0.05) day to day for all cows, no treatment effects occurred (P > 0.10). Although Cu bolus administration at this concentration did tend to change Cu copper in the animal, effects resulting from it were minimal.

中文翻译：

---

80 铜丸给药对循环铜浓度、血液代谢物和寄生虫负荷的影响

在德克萨斯州和美国东南部，土壤中的铜浓度处于较低的 50%，这导致牲畜铜的生物利用度较低。因此，进行了一项为期 70 天的完全随机区组设计研究，以确定铜和粪便鸡蛋计数对放牧肉牛 (n = 40) 的影响。根据胎次和体重 (BW) 对奶牛进行分组，然后随机分配到 2 种处理中的 1 种：通过自由选择矿物质（CON；Ragland Sweet Mag 矿物质混合物，425 ppm Cu）提供标准铜，以及接受 25 毫克铜瘤胃推注的奶牛除了标准产品（德克萨斯州达拉斯圣克鲁斯动物健康公司）。牛群被作为一个群体进行管理，并享有平等的饮水、谷物补充和暖季草场。通过直肠抓取的粪便样本、通过尾骨静脉穿刺的血液、BW、BCS、毛皮（1 是最健康的）和脱落（1 是最光滑的）评分均在第 0、10、24、38 和 66 天收集。治疗开始。分析血清以确定循环铜、大量矿物质、尿素、肌酐和各种血液蛋白。进行粪便虫卵计数以确定球虫、莫尼齐虫和毛圆线虫虫卵含量。使用 SAS 9.4 (SAS inst. Inc, Cary, NC) 的 GLIMMIX 程序分析数据。没有观察到循环铜的处理×天数交互作用（P = 0.988）；然而，随着时间的推移，所有牛的铜含量均下降（P < 0.001），并且与 CON 相比，TRT 倾向于增加铜含量（P = 0.090）。BW 没有发生相互作用或主效应（P > 0.509）。BCS、头发或脱落分数没有发生交互作用 (P = 0.4389)。随着时间的推移，所有牛的毛发评分（P < 0.001）、脱落评分（P < 0.041）和 BCS（P < 0.001）均下降。TRT 的身体状况 (5.2 ± 0.056) 优于 CON (4.9 ± 0.057) (P =.0024)。TRT 中毛发评分逐日下降（P < 0.001），而 TRT 中脱落量有增加的趋势（P = 0.0411）。对球虫（P < 0.220）或毛圆线虫（P < 0.274）卵含量没有相互作用或主要影响。虽然没有观察到莫尼齐亚的相互作用 (P = 0.673)，但 TRT 的莫尼齐亚卵往往比 CON 少 (P = 0.095)。没有观察到任何血液代谢物之间的相互作用（P>0.100），并且虽然所有奶牛的代谢物每天都不同（P<0.05），但没有发生治疗效果（P>0.10）。尽管此浓度的铜推注确实会改变动物体内的铜铜含量，但其产生的影响却很小。