This study investigates the expression and significance of urinary protein and coagulation-fibrinolysis indicators in preeclampsia, categorized into mild preeclampsia (109 cases) and severe preeclampsia (97 cases) based on disease severity. Additionally, 110 patients with gestational hypertension (gestational hypertension group) were included for comparative analysis. General information, laboratory indicators, urinary protein, and coagulation-fibrinolysis indicator levels were collected for each group. Significant differences were observed in blood pressure among groups (P < .05), while uric acid, serum creatinine, aspartate transaminase, alanine transaminase, and triglycerides showed no significant differences (P > .05). Total cholesterol, triglycerides, and low-density Lipoprotein levels in severe preeclampsia were higher than those in mild preeclampsia and gestational hypertension groups, whereas high-density lipoprotein, albumin, and platelet levels were lower in severe preeclampsia. No significant differences were observed in prothrombin time or D-dimer levels among groups (P > .05). Urinary protein, urinary protein quantification, activated partial thromboplastin time, thrombin time, and fibrinogen were identified as influencing factors for adverse maternal and infant outcomes in severe preeclampsia patients. The study concludes that urinary protein and coagulation-fibrinolysis indicators are elevated in preeclampsia, particularly in severe preeclampsia cases, suggesting their potential use as diagnostic influencing factors for severe preeclampsia.

中文翻译：

---

子痫前期尿蛋白和凝血纤溶指标的表达及意义

本研究探讨子痫前期尿蛋白和凝血纤溶指标的表达及意义，根据病情严重程度分为轻度子痫前期（109例）和重度子痫前期（97例）。另纳入110例妊娠期高血压患者（妊娠期高血压组）进行对比分析。收集各组一般资料、实验室指标、尿蛋白、凝血纤溶指标水平。各组间血压差异有统计学意义（P  < .05），而尿酸、血清肌酐、天冬氨酸转氨酶、丙氨酸转氨酶、甘油三酯差异无统计学意义（P  > .05）。重度子痫前期组总胆固醇、甘油三酯、低密度脂蛋白水平高于轻度子痫前期组和妊娠期高血压组，而重度子痫前期组高密度脂蛋白、白蛋白、血小板水平较低。各组间凝血酶原时间或 D-二聚体水平未观察到显着差异 ( P  > .05)。尿蛋白、尿蛋白定量、活化部分凝血活酶时间、凝血酶时间和纤维蛋白原被确定为严重子痫前期患者母婴不良结局的影响因素。该研究得出的结论是，尿蛋白和凝血纤溶指标在先兆子痫中升高，特别是在严重先兆子痫病例中，表明它们有可能用作严重先兆子痫的诊断影响因素。