To compare the urine Congo-red dot paper test (CRD) with dipstick urinalysis to screen preeclampsia (PE). A total of 409 paired spot urine samples were obtained prospectively from women with suspected pre-eclampsia attending for routine hospital visits. Congo-red dot paper test and dipstick urinalysis were examined and compared to screen pre-eclampsia. The agreement between the two urinary test is modest (kappa coefficient = 0.28, 95% CI 0.14–0.42). The specificity of CRD was higher than urinalysis (97.4% vs. 90.4%, p < .001). Urinalysis performed better in sensitivity (77.3% vs. 40.9%, p = .04) and the area under the receiver operating characteristic curves (AUC) (0.84 [95% CI 0.74–0.94] vs. 0.69 [95% CI 0.55–0.83], p = .04) than CRD, respectively. The sensitivity, specificity, AUC of the parallel test of them is 86.4% (64.0%–96.4%), 89.1% (85.5%–92.0%), and 0.88 (95% CI 0.79–0.96). And the serial test is 31.8% (14.7%–54.9%), 98.7% (96.8%–99.5%), 0.65 (95% CI 0.51–0.79), accordingly. The urinalysis is a better diagnosing test for preeclampsia. CRD could aid in the diagnosis of patients with preeclampsia. Combined the two tests in suspected patients may further improve the performance in the diagnosis of preeclampsia. Further study need to be made for its potential clinical practice.

中文翻译：

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比较尿液即时检测筛查先兆子痫：刚果红点纸测试与试纸尿液分析

比较尿液刚果红点试纸试验 (CRD) 与试纸尿液分析筛查先兆子痫 (PE) 的效果。前瞻性地从定期去医院就诊的疑似先兆子痫的女性中采集了总共 409 份配对的尿样。检查刚果红点试纸测试和试纸尿液分析，并与筛查先兆子痫进行比较。两次尿液测试之间的一致性不大（kappa 系数 = 0.28，95% CI 0.14–0.42）。 CRD 的特异性高于尿液分析（97.4% vs. 90.4%，p <  .001）。尿液分析在灵敏度（77.3% vs. 40.9%， p  = .04）和受试者工作特征曲线下面积 (AUC)（0.84 [95% CI 0.74–0.94] vs. 0.69 [95% CI 0.55–0.83]）方面表现更好], p  = .04) 分别高于 CRD。其平行试验的敏感性、特异性、AUC分别为86.4%（64.0%~96.4%）、89.1%（85.5%~92.0%）和0.88（95% CI 0.79~0.96）。相应地，系列测试为31.8%（14.7%–54.9%）、98.7%（96.8%–99.5%）、0.65（95% CI 0.51–0.79）。尿液分析是先兆子痫更好的诊断测试。 CRD 可以帮助诊断先兆子痫患者。在疑似患者中结合这两种测试可能会进一步提高子痫前期的诊断性能。其潜在的临床实践需要进一步研究。